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SIAH2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marke:  Proteintech 12651-1-AP-150UL

Additional Details : Gewicht : 0.00010kg

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Artikelnummer. 16840484

  • 351.68 CHF / 150 Mikroliter

Verfügbar ab: 28-06-2022
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Beschreibung

Beschreibung

SIAH-2 (seven in absentia homolog 2) is an E3 ligase that catalyzes ubiquitination and proteasome-mediated degradation of protein substrates. SIAH-2 encodes a 324 amino acid protein that shares 77% identity with human SIAH-1 and 68% identity with the Drosophila sina (seven in absentia) gene, on which development of the Drosophila R7 photoreceptor is dependent. SIAH-2 targets TRAF2 (which regulates cell responses to stress and cytokines through the regulation of key stress-signaling cascades) for degradation under stress conditions such as hypoxia. It targets HIF-1 alpha prolyl hydroxylase 3 (PHD3) for degradation upon exposure to hypoxic conditions, which coincides with an increase in SIAH-2 transcription. SIAH-2 can decrease TNF-alpha-dependent induction of JNK activity and transcriptional activation of NFkB. SIAH-2 null mice subjected to hypoxia display an impaired respiratory response and reduced levels of hemoglobin.
Spezifikation

Spezifikation

SIAH2
Polyclonal
Unconjugated
SIAH2
hSiah2, Seven in absentia homolog 2, Siah 2, SIAH2
Rabbit
Antigen Affinity Chromatography
RUO
140593, 20439, 6478
Antibody
IgG
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
0.27 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
O43255, Q06986, Q8R4T2
SIAH2
SIAH2 Fusion Protein Ag3342
150 μL
Primary
Human, Mouse, Rat
Liquid
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation
Zertifikate
Sonderangebote

Sonderangebote