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SIAH2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

133.80 CHF - 381.34 CHF

Spezifikation

Antigen SIAH2
Konzentration 0.27 mg/mL
Anwendungen Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry, Immunoprecipitation, Immunofluorescence
Klassifikation Polyclonal
Konjugat Unconjugated
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Produkte 2
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
16850484
Unterlagen ansehen Aktionsdetails
Proteintech
12651-1-AP-20UL
20 μL
133.80 CHF
20 Mikroliter
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Verfügbar ab: 16-04-2024
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16840484
Unterlagen ansehen Aktionsdetails
Proteintech
12651-1-AP-150UL
150 μL
381.34 CHF
150 Mikroliter
Alternative Produkte anzeigen
Sparen Sie bis zu 
»
Verfügbar ab: 16-04-2024
Sie sich ein, um den Lagerbestand zu sehen
Zum Warenkorb hinzufügen
 
Beschreibung

Beschreibung

SIAH-2 (seven in absentia homolog 2) is an E3 ligase that catalyzes ubiquitination and proteasome-mediated degradation of protein substrates. SIAH-2 encodes a 324 amino acid protein that shares 77% identity with human SIAH-1 and 68% identity with the Drosophila sina (seven in absentia) gene, on which development of the Drosophila R7 photoreceptor is dependent. SIAH-2 targets TRAF2 (which regulates cell responses to stress and cytokines through the regulation of key stress-signaling cascades) for degradation under stress conditions such as hypoxia. It targets HIF-1 alpha prolyl hydroxylase 3 (PHD3) for degradation upon exposure to hypoxic conditions, which coincides with an increase in SIAH-2 transcription. SIAH-2 can decrease TNF-alpha-dependent induction of JNK activity and transcriptional activation of NFkB. SIAH-2 null mice subjected to hypoxia display an impaired respiratory response and reduced levels of hemoglobin.
Spezifikation

Spezifikation

SIAH2
Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry, Immunoprecipitation, Immunofluorescence
Unconjugated
Rabbit
Mouse, Human, Rat
O43255, Q06986, Q8R4T2
140593, 20439, 6478
SIAH2 Fusion Protein Ag3342
Primary
-20°C
SIAH2
0.27 mg/mL
Polyclonal
Liquid
RUO
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
hSiah2, Seven in absentia homolog 2, Siah 2, SIAH2
SIAH2
IgG
Antigen Affinity Chromatography
Antibody
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

Dokumentation

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