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RPH3A Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marke:  Proteintech 11396-1-AP-150UL

Additional Details : Gewicht : 0.00010kg

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Artikelnummer. 16838443

  • 351.68 CHF / 150 Mikroliter

Verfügbar ab: 01-07-2022
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Beschreibung

Beschreibung

The carboxy-terminal of rabphilin-3A consists of two C2 domains, A and B,and the amino-terminal (residues 45-170) contains a cysteine-rich rich region with two zinc finger motifs. Rabphilin-3A belongs to a family of other carboxyterminal type (C-type) tandem C2 proteins, which includes synaptotagmins and Doc2. Rabphilin is expressed in neuroendocrine cells and co-localizes with Rab3A on synaptic vesicles and chromaffin granules. Rabphilin-3A binds Rab3a/GTP/Mg+ within amino-terminal residues 45 and 170. Rabphilin-3A binds calcium ions and phosphatidylinositol 4,5-bisphophate containing lipid vesicles within its C2 domains. Rabphilin-3A is a positive regulator of calcium dependent exocytosis, while Rab3a is a negative regulator of exocytosis. Although rabphilin-3A associates with Rab3a, they seem to influence exocytosis independently of each other. Rabphilin-3A effects are likely mediated through interactions with an unknown factor that recognizes the Rab3 binding domain.
Spezifikation

Spezifikation

RPH3A
Polyclonal
Unconjugated
RPH3A
Exophilin 1, KIAA0985, Rabphilin 3A, rabphilin 3A homolog (mouse), RPH3A
Rabbit
Antigen Affinity Chromatography
RUO
171039, 19894, 22895
Antibody
IgG
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
0.2 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
P47708, P47709, Q9Y2J0
Rph3a
RPH3A Fusion Protein Ag1956
150 μL
Primary
Human, Mouse, Rat
Liquid
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation
Zertifikate
Sonderangebote

Sonderangebote