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RPH3A Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Marke: Proteintech 11396-1-AP-150UL
Additional Details : Gewicht : 0.00010kg
Beschreibung
The carboxy-terminal of rabphilin-3A consists of two C2 domains, A and B,and the amino-terminal (residues 45-170) contains a cysteine-rich rich region with two zinc finger motifs. Rabphilin-3A belongs to a family of other carboxyterminal type (C-type) tandem C2 proteins, which includes synaptotagmins and Doc2. Rabphilin is expressed in neuroendocrine cells and co-localizes with Rab3A on synaptic vesicles and chromaffin granules. Rabphilin-3A binds Rab3a/GTP/Mg+ within amino-terminal residues 45 and 170. Rabphilin-3A binds calcium ions and phosphatidylinositol 4,5-bisphophate containing lipid vesicles within its C2 domains. Rabphilin-3A is a positive regulator of calcium dependent exocytosis, while Rab3a is a negative regulator of exocytosis. Although rabphilin-3A associates with Rab3a, they seem to influence exocytosis independently of each other. Rabphilin-3A effects are likely mediated through interactions with an unknown factor that recognizes the Rab3 binding domain.Spezifikation
RPH3A | |
Polyclonal | |
Unconjugated | |
RPH3A | |
Exophilin 1, KIAA0985, Rabphilin 3A, rabphilin 3A homolog (mouse), RPH3A | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
171039, 19894, 22895 | |
-20°C | |
Liquid |
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot | |
0.2 mg/mL | |
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 | |
P47708, P47709, Q9Y2J0 | |
Rph3a | |
RPH3A Fusion Protein Ag1956 | |
150 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |