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ROCK1 Mouse anti-Human, Mouse, Rat, Clone: 3G5E12, Proteintech

Mouse Monoclonal Antibody

131.19 CHF - 351.68 CHF

Spezifikation

Antigen ROCK1
Konzentration 0.8 mg/mL
Anwendungen Western Blot
Klassifikation Monoclonal
Konjugat Unconjugated
Mehr Spezifikationen ansehen

Produkte 2
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
16838975
Unterlagen ansehen Aktionsdetails
Proteintech
66782-1-IG-150UL
150 μL
351.68 CHF
150 Mikroliter
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Verfügbar ab: 12-08-2022
Sie sich ein, um den Lagerbestand zu sehen
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16848975
Unterlagen ansehen Aktionsdetails
Proteintech
66782-1-IG-20UL
20 μL
131.19 CHF
20 Mikroliter
Alternative Produkte anzeigen
Sparen Sie bis zu 
»
Verfügbar ab: 12-08-2022
Sie sich ein, um den Lagerbestand zu sehen
Zum Warenkorb hinzufügen
 
Beschreibung

Beschreibung

The Rho target protein, Rho-associated coiled coil-containing protein kinase (ROCK)-1 has been found to be a new Caspase-3 substrate. ROCK, one of the effectors of the small GTPase Rho, has recently been shown to contribute significantly to myosin light chain (MLC) activation through two pathways: direct phosphorylation of MLC and phosphorylation of MLC phosphatase, leading to its inhibition. The increase in cellular contractility that is necessary for apoptotic membrane blebbing implies sustained augmentation of MLC phosphorylation. ROCK-1 consists of an amino-terminal kinase domain and an inhibitory cysteine/histidine-rich C-terminal domain that is located within a pleckstrin-homology region. They are joined by a variable region that contains the Rho-binding domain. During apoptosis, ROCK-I is cleaved by caspase-3 at a conserved DETD1113/G sequence and its carboxy-terminal inhibitory domain is removed, resulting in deregulated and constitutive kinase activity. The caspase-3-mediated cleavage and activation of ROCK I induces phosphorylation of MLC and membrane blebbing, one of the first events in the execution phase of apoptosis.
Spezifikation

Spezifikation

ROCK1
Western Blot
Unconjugated
Mouse
Rat, Mouse, Human
IgG1
-20°C
0.8 mg/mL
Monoclonal
Liquid
RUO
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Protein G
Antibody
Sicherheitsdatenblatt (SDS)
Product Certifications