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Ly-51 Rat anti-Mouse, FITC, Clone: 6C3, BD
Rat Monoclonal Antibody
230.00 CHF - 857.00 CHF
Spezifikation
Antigen | Ly-51 |
---|---|
Klon | 6C3 |
Konzentration | 0.5mg/mL |
Anwendungen | Flow Cytometry |
Klassifikation | Monoclonal |
Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
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Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
15801609
|
BD Biosciences
562057 |
50 μg |
230.00 CHF
1 Stück |
Verfügbar ab: 23-05-2024
Loggen Sie sich ein, um den Lagerbestand zu sehen |
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15817048
|
BD Biosciences
553160 |
0.5 mg |
Dieser Artikel wurde eingestellt und ist leider nicht mehr verfügbar. Sehen Sie sich das Produkt an, um alternative Produktvorschläge zu sehen oder kontaktieren Sie unseren Technischen Support unter 056 618 41 11. |
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Beschreibung
The 6C3 antibody reacts with an epitope of the 6C3/BP-1 (Ly-51) glycoprotein cell-surface differentiation antigen, which was originally identified on pre-B cell lymphomas (spontaneous and chemical- or retrovirus- transformed, in vitro and in vivo). 6C3/BP-1 is a homodimer cell-surface glycoprotein with 140-kDa subunits which has been identified to possess aminopeptidase A (APA) activity. The same antigen is expressed at high levels on bone marrow stromal cell lines which support in vitro B lymphopoieses, on thymic dendritic cells and cortical epithelial cells, and on a wide variety of mouse and rat tissues known to possess APA activity. Subsets of normal bone marrow pre-B and B lymphocytes express low levels of Ly-51, which is rapidly up-regulated on the pre-B cells in the presence of IL-7. A role for the 6C3/BP-1 molecule in the IL-7-driven proliferation of B cell precursors has been postulated. However, B-cell abnormalities were not detected in Ly-51-deficient mice. Mature B lymphocytes, thymocytes, peripheral T lymphocytes, erythroid cells, and myeloid cells (with the exception of thymic dendritic cells) do not express Ly-51. The 6C3 antibody can be used to identify cortical epithelium in frozen sections of thymuses from normal, SCID, and TCR-transgenic mice. It is possible that the low level of 6C3/BP-1 antigen detected, by flow cytometry, on some thymocytes may be passively adsorbed from adjacent epithelial cells during preparation of the cell suspensions.
Spezifikation
Ly-51 | |
0.5mg/mL | |
Monoclonal | |
Rat | |
Mouse | |
C57L mouse Pre-B lymphhoma cell line L1-2 | |
Primary | |
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
6C3 | |
Flow Cytometry | |
FITC | |
RUO | |
Aqueous buffered solution containing ≤0.09% sodium azide. | |
IgG2a κ | |
Affinity Purified | |
6C3/BP-1 Antigen |
For Research Use Only.