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IRAK4 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marke:  Proteintech 18221-1-AP-20UL

Additional Details : Gewicht : 0.00010kg

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Artikelnummer. 16838284

  • 131.19 CHF / 20 Mikroliter

Verfügbar ab: 28-06-2022
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Beschreibung

Beschreibung

Interleukin-1 (IL-1) and lipopolysaccharide (LPS) induces cellular responses through IL-1 receptor (IL-1R) and Toll-like receptors (TLR). IL-1R-associated kinases (IRAK, IRAK2, and IRAK-M) regulate the activation of NF-kappa-B and MAP kinase (MAPK) by IL-1R/TLR. A novel member in the IRAK/Pelle family was recently identified and designated IRAK-4. Overexpression of IRAK-4 activates NF-kappa-B and MAPK pathways. IRAK-4 interacts with and phosphorylates IRAK-1. IRAK-4-deficient animals are completely resistant to the challenge with LPS. Animals and humans lacking IRAK-4 are impaired in their responses to viral and bacterial challenges. Members in IRAK/Pelle family play a central role in IL-1R/TLR mediated inflammatory responses and in innate immunity.
Spezifikation

Spezifikation

IRAK4
Polyclonal
Unconjugated
IRAK4
IPD1, IRAK 4, IRAK4, NY REN 64, REN64
Rabbit
Antigen Affinity Chromatography
RUO
266632, 300177, 51135
Antibody
IgG
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
0.13 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Q8R4K2, Q9NWZ3
IRAK4
IRAK4 Fusion Protein Ag12982
20 μL
Primary
Mouse, Rat, Human
Liquid
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation
Zertifikate
Sonderangebote

Sonderangebote