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ACROBiosystems Human Fc gamma RIIB / CD32b Protein, His Tag
SPR & BLI verified
277.42 CHF - 2522.00 CHF
Spezifikation
Zugriffsnummer | NP_001002273.1 |
---|---|
Molekulargewicht | 20.4 kDa |
Quelle | Human CD32b, His Tag (SPR and BLI verified) (CDB-H5228) is expressed from human 293 cells (HEK293). It contains AA Ala 46 - Pro 217 (Accession # P31994). |
Immunogen | Ala 46 - Pro 217 |
Lagerungsbedingungen | -20°C |
Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
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Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
15816367
|
ACROBiosystems
CDB-H5228-100UG |
100 μg |
353.08 CHF
100 Mikrogramm |
Verfügbar ab: 14-05-2024
Loggen Sie sich ein, um den Lagerbestand zu sehen |
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15826367
|
ACROBiosystems
CDB-H5228-1MG |
1 mg |
2522.00 CHF
1 Milligramm |
Verfügbar ab: 14-05-2024
Loggen Sie sich ein, um den Lagerbestand zu sehen |
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17136201
|
ACROBiosystems
CDB-H5228-50UG |
50 μg |
277.42 CHF
50 Mikrogramm |
Verfügbar ab: 14-05-2024
Loggen Sie sich ein, um den Lagerbestand zu sehen |
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Beschreibung
Receptors for the Fc region of IgG (Fc γ R) are members of the Ig superfamily that function in the activation or inhibition of immune responses. Three classes of human Fc γ Rs: RI (CD64), RII (CD32), and RIII (CD16), which generate multiple isoforms, are recognized. There are three genes for human Fcγ RII /CD32 (A, B, and C) and one for mouse Fcγ RII B (CD32B). CD32 is a low affinity receptor for IgG. Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B) is also known as CD32b, FCG2, IGFR2. CD32B is expressed on B cells and myeloid dendritic cells. Ligation of CD32B on B cells downregulates antibody production and may, in some circumstances, promote apoptosis. Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation. CD32B may also be a target for monoclonal antibody therapy for malignancies.
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 20.4 kDa. The protein migrates as 25-33 kDa under reducing (R) condition (SDS-PAGE) due to different glycosylation.Spezifikation
NP_001002273.1 | |
Human CD32b, His Tag (SPR and BLI verified) (CDB-H5228) is expressed from human 293 cells (HEK293). It contains AA Ala 46 - Pro 217 (Accession # P31994). | |
-20°C | |
Fc gamma RIIB / CD32b | |
Human | |
PBS, pH7.4 | |
HEK293 | |
MABSol™ Fc Receptors |
20.4 kDa | |
Ala 46 - Pro 217 | |
FCGR2B,CD32b,CD32,FCG2,IGFR2,CDw32 | |
Unconjugated | |
His Tag | |
Less than 1.0 EU / μg by the LAL method. | |
Powder | |
>95% as determined by SDS-PAGE |