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ACROBiosystems Human Fc gamma RIIB / CD32b Protein, His Tag
SPR & BLI verified
Marke: ACROBiosystems CDB-H5228-1MG
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Beschreibung
Receptors for the Fc region of IgG (Fc γ R) are members of the Ig superfamily that function in the activation or inhibition of immune responses. Three classes of human Fc γ Rs: RI (CD64), RII (CD32), and RIII (CD16), which generate multiple isoforms, are recognized. There are three genes for human Fcγ RII /CD32 (A, B, and C) and one for mouse Fcγ RII B (CD32B). CD32 is a low affinity receptor for IgG. Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B) is also known as CD32b, FCG2, IGFR2. CD32B is expressed on B cells and myeloid dendritic cells. Ligation of CD32B on B cells downregulates antibody production and may, in some circumstances, promote apoptosis. Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation. CD32B may also be a target for monoclonal antibody therapy for malignancies.
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 20.4 kDa. The protein migrates as 25-33 kDa under reducing (R) condition (SDS-PAGE) due to different glycosylation.Spezifikation
| NP_001002273.1 | |
| 1 mg | |
| Ala 46 - Pro 217 | |
| FCGR2B,CD32b,CD32,FCG2,IGFR2,CDw32 | |
| Unconjugated | |
| His Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >95% as determined by SDS-PAGE |
| 20.4 kDa | |
| Human CD32b, His Tag (SPR and BLI verified) (CDB-H5228) is expressed from human 293 cells (HEK293). It contains AA Ala 46 - Pro 217 (Accession # P31994). | |
| -20°C | |
| Fc gamma RIIB / CD32b | |
| Human | |
| PBS, pH7.4 | |
| HEK293 | |
| MABSol™ Fc Receptors |