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CD274 Mouse anti-Human, PE, Clone: MIH1, BD
Mouse Monoclonal Antibody
Marke: BD Biosciences 557924
Additional Details : Gewicht : 0.02000kg
Beschreibung
PD-L1 and PD-L2 are newly discovered members of the B7 family are the ligands for the program death 1 (PD-1) receptor. They are expressed on immature dendritic cells and mature dendritic cells. PD-L1, also called B7-H1, is expressed on antigen-presenting cells, including IFN- γ-stimulated monocytes, and activated human and murine dendritic cells. Monoclonal antibodies that block PD-L1 and PD-L2 on dendritic cells result in enhanced T cell proliferation and cytokine production. PD-L1 is also expressed on placental trophoblasts, myocardial endothelium, cortical thymic epithelial cells, and on most carcinomas. Studies show overlapping functions of PD-L1 and PD-L2 and indicate an important role for the PD-L:PD-1 pathway in regulating T cell responses.
Spezifikation
| CD274 | |
| Monoclonal | |
| PE | |
| Aqueous buffered solution containing BSA and ≤0.09% sodium azide. | |
| Affinity Purified | |
| RUO | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
| Flow Cytometry | |
| MIH1 | |
| B7-H1, PD-L1 | |
| Mouse | |
| 100 Tests | |
| Immunology | |
| Human | |
| IgG1 κ |
For Research Use Only.