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ARPP-21 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marke:  Proteintech 11829-1-AP-20UL

Additional Details : Gewicht : 0.00010kg

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Artikelnummer. 16839163

  • 131.19 CHF / 20 Mikroliter

Verfügbar ab: 28-06-2022
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Beschreibung

Beschreibung

The autosomal domit cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure′ cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known. This locus has been mapped to chromosome 6, and it has been determined that the diseased allele contains 41-81 CAG repeats, compared to 6-39 in the normal allele, and is associated with spinocerebellar ataxia type 1 (SCA1). At least two transcript variants encoding the same protein have been found for this gene.
Spezifikation

Spezifikation

ARPP-21
Polyclonal
Unconjugated
ARPP21
ARPP 21, ARPP21, ARPP-21, RCS, TARPP
Rabbit
Antigen Affinity Chromatography
RUO
10777, 363153, 74100
Antibody
IgG
Western Blot, Immunohistochemistry (Paraffin)
0.38 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Q9DCB4, Q9UBL0
Arpp21
ARPP-21 Fusion Protein Ag2399
20 μL
Primary
Rat, Human, Mouse
Liquid
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation
Zertifikate
Sonderangebote

Sonderangebote