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CD279 Mouse anti-Human, FITC, Clone: MIH4, BD

Mouse Monoclonal Antibody

Marke:  BD Biosciences 561035

Additional Details : Gewicht : 0.01000kg

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Artikelnummer. 15830709

  • 151.00 CHF / 1 Stück


Verfügbar ab
03-06-2021
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Beschreibung

Beschreibung

The MIH4 monoclonal antibody specifically binds to the program death 1 (PD-1) receptor CD279, a member of the Ig superfamily. CD279 is an immunoregulatory receptor expressed on activated T cells, B cells and myeloid cells. Mice deficient in CD279 show a breakdown of peripheral tolerance and manifest multiple autoimmune symptoms. It contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region. PD-L1 and PD-L2 are ligands of CD279 and are members of the B7 gene family. Interaction of CD279:PD-Ligands results in inhibition of T cell proliferation and cytokine secretion. Reports suggest that the B7/CTLA-4 pathway functions primarily to attenuate, limit, and/or terminate naοve T-cell activation in secondary lymphoid organs. The PD-ligand:CD279 pathway, on the other hand, may primarily attenuate, limit, and/or terminate T-, B-, and myeloid cell activation/effector function at sites of inflammation in the periphery.

Spezifikation

Spezifikation

CD279
MIH4
FITC
Aqueous buffered solution containing ≤0.09% sodium azide.
Murine
IgG1, κ
RUO
Primary
Human
Flow Cytometry
0.5mg/mL
PD-1; hPD-1; PD1; PDCD1; Programmed cell death 1; SLEB2
Affinity Purified
Human PD-1 Transfected Cell Line
25μg
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

For Research Use Only.