missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Antibodies
  4. Primary Antibodies
  5. All Primary Antibodies
  6. 10342463

Invitrogen™ ZO-1 Polyclonal Antibody

Codice prodotto. 10342463
Cambia vista
Click to view available options
Quantità:
100 μg
Dimensione della confezione:
100µg
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Codice prodotto. Quantità Dimensione della confezione
10342463 100 μg 100µg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
Les retours ne sont pas autorisés pour ce produit. Consulta la politica di reso
Codice prodotto. 10342463 Fornitore Invitrogen™ N. del fornitore 617300
  • ONLINE EXCLUSIVE PRICE
    750.00 CHF
    562.65 CHF / 100 Mikrogramm
    Sparen 187.35 CHF
    24% Rabatt
View all promotions
 Articolo soggetto a restrizioni
Lager vorrätig
Add to basket
Edge
532.00 CHF valido fino al 2026-12-18
MIGLIOR PREZZO in promozione! Usa il codice promo "27967" per avere il tuo prezzo promozionale.
Add to basket

missing translation for 'validMainframeMsg'

This item is not returnable. View return policy

Description

Rabbit Polyclonal Antibody

61-7300 has been successfully used in Western blot, Immunoprecipitation, Immunofluorescence, ELISA and Immunohistochemistry. To achieve appropriate staining results on formalin-fixed, paraffin embedded tissue sections, protease Type XIV (Actinase E) pretreatment is required. The recommended dilution and incubation for protease is 1-2 mg/mL at 37°C for 10 minutes. Other enzyme and Heat Induced Epitope Retrieval pre-treatment methods may not be suitable for this particular antibody. Frozen sections have been successfully stained after fixation with acetone at 4°C.

ZO-1 forms complexes with either ZO-2 or ZO-3. In addition, these proteins can also associate with claudin, occludin and F-actin, at tight junction stands, where they provide a linkage between the actin cytoskeleton and the tight junction. ZO-1 expression is significantly reduced in many breast cancer lines. ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue. ZO-1 is a protein located on a cytoplasmic membrane surface of intercellular tight junctions. ZO-1 may be involved in signal transduction at cell-cell junctions. Two transcript variants encoding distinct isoforms have been identified for the ZO-1 gene. Diseases associated with ZO-1 dysfunction include Celiac Disease and Congenital Nephrotic Syndrome.
TRUSTED_SUSTAINABILITY

Specifications

Antigene ZO-1
Applicazioni ELISA, Immunohistochemistry, Immunoprecipitation, Western Blot, Immunocytochemistry
Classificazione Polyclonal
Concentrazione 0.25 mg/mL
Coniugato Unconjugated
Formulazione PBS with 0.1% sodium azide; pH 7.4
Gene TJP1
N. accesso geni O97758, P39447, Q07157
Alias gene DKFZp686M05161; I79_005485; MGC133289; OTTHUMP00000174520; Tight junction protein 1; tight junction protein 1 (zona occludens 1); tight junction protein ZO-1; Tjp1; zo1; ZO-1; ZO-1 MDCK; zona occludens 1; zona occludens protein 1; zonula occludens 1; zonula occludens 1 protein; zonula occludens protein 1
Simboli geni TJP1
Specie ospite Rabbit
Immunogeno A 69 kD fusion protein(1) corresponding to amino acids 463-1109 of human ZO-1 cDNA.(2) This sequence lies N-terminal to the 80 amino acid region (the alpha-motif) present in the a+-isoform but absent in the a- isoform due to alternative splicing.
Metodo di purificazione Antigen affinity chromatography
Quantità 100 μg
Status giuridico RUO
Primario o secondario Primary
ID gene (immissione) 100718142, 21872, 292994, 403752, 7082
Target Species Canine, Guinea Pig, Human, Mouse, Monkey, Rat
Content And Storage -20°C
Product Type Antibody
Forma Liquid
Isotype IgG
Show More Show Less
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.