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XPG Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marke:  Proteintech 11331-1-AP-150UL

Additional Details : Gewicht : 0.00010kg

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Artikelnummer. 16838333

  • 351.68 CHF / 150 Mikroliter

Verfügbar ab: 28-06-2022
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Beschreibung

Beschreibung

Xeroderma pigmentosum type G (XPG) is a human genetic disease exhibiting extreme sensitivity to sunlight. The XPG protein, a member of the flap endonuclease 1 (FEN-1) structure-specific DNA repair endonuclease family, is an enzyme essential for DNA repair of the major kinds of solar ultraviolet (UV)-induced DNA damages. Human XPG nuclease makes the 3′ incision during nucleotide excision repair of DNA. The enzyme cleaves model DNA bubble structures specifically near the junction of unpaired DNA with a duplex region. A 29-amino acid region of human XPG (residues 981-1009) contains the PCNA binding activity. A conserved arginine in XPG (Arg992) is crucial for its PCNA binding activity. Replication Protein A (RPA) binds specifically and directly to two excision repair proteins, the xeroderma pigmentosum damage-recognition protein XPA and the endonuclease XPG.
Spezifikation

Spezifikation

XPG
Polyclonal
Unconjugated
ERCC5
COFS3, ERCC5, ERCM2, UVDR, XPG, XPGC
Rabbit
Antigen Affinity Chromatography
RUO
2073
Antibody
IgG
Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
0.19 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
P28715
ERCC5
XPG Fusion Protein Ag1874
150 μL
Primary
Human
Liquid
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation
Zertifikate
Sonderangebote

Sonderangebote