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VTCN1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marke:  Proteintech 12080-1-AP-20UL

Additional Details : Gewicht : 0.00010kg

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Artikelnummer. 16839583

  • 131.19 CHF / 20 Mikroliter

Verfügbar ab: 28-06-2022
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Beschreibung

Beschreibung

B7-H4 (B7x, VTCN1) a costimulatory protein which is reported to function as a negative regulator of T-cell mediated immunity. Although B7-H4 binds an unknown receptor, it is thought to deliver an inhibitory signal to T-cells preventing their proliferation, cell cycle progression and interleukin-2 production. B7-H4 deficient mice are only minimally affected; suggesting B7-H4 is important in the fine tuning of the T-cell mediated immune response. B7-H4 is expressed on activated T-cells, B-cells, monocytes and dendritic cells. Aberrant expression has been associated with cancers of the lung, breast and ovary in humans. B7-H4 is expressed primarily on the membrane of lymphoid cells, and as an immunoinhibitory protein that interacts with receptors on the surface of T lymphocytes, it is involved in mediating cellular and humoral immune responses. Overexpression of B7-H4 is associated with certain maligcies, including ovarian and breast cancer, which may be a mechanism by which tumor cells suppress T cell immunity and facilitate tumor progression. Further, VTCN1 may be a useful biomarker for the early detection of ovarian cancer and Renal Cell Carcinoma (RCC).
Spezifikation

Spezifikation

VTCN1
Polyclonal
Unconjugated
VTCN1
B7 H4, B7h.5, B7H4, B7S1, B7X, PRO1291, Protein B7S1, RP11 229A19.4, VCTN1, VTCN1
Rabbit
Antigen Affinity Chromatography
RUO
242122, 295322, 79679
Antibody
IgG
Western Blot, Immunohistochemistry (Paraffin)
0.23 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Q501W4, Q7TSP5, Q7Z7D3
VTCN1
VTCN1 Fusion Protein Ag2712
20 μL
Primary
Rat, Mouse, Human
Liquid
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation
Zertifikate
Sonderangebote

Sonderangebote