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Thermo Scientific Chemicals U-73122, 95 %
Beschreibung
It is used as a phospholipase C, phospholipase A2, and 5-LO inhibitor. It is also determined that in SK-N-SH neuroblastoma cells, U-73122 inhibits agonist-induced down-regulation of muscarinic receptors. In addition, it is a useful tool to investigate receptor-mediated PI turnover in signal transduction. U-73122 is a potent inhibitor of human neutrophil adhesion to biological surfaces (IC50 = 50 nM) as well as adhesion-dependent granule exocytosis and oxidative burst. U-73343 (sc-201422) is useful as a negative control for investigations of U-73122 phospholipase C antagonism and its cellular consequences.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Spezifikation
Spezifikation
| Menge | 1 mg |
| Beschreibung | Weißgrau |
| Zur Verwendung mit (Anwendung) | Hemmt die Phospholipase C-Aktivierung und Runterregulierung von muskarinischen Rezeptoren |
| Formelmasse | 464,65g/mol |
| Löslichkeit | Löslich in DMSO, Ethanol oder DMF bei ca. 0,5 mg/ml; Erhitzen oder Mischen über Nacht erforderlich; unlöslich in Wasser |
| Produkttyp | Signaltransduktionsreagenz |
| Form | Kristalliner Feststoff |
| Assay | 99% |
RUO – Research Use Only
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