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Tyrosine Hydroxylase Polyclonal Antibody, Invitrogen™
Goat Polyclonal Antibody
Marke: Invitrogen PA518372
Additional Details : Gewicht : 0.01000kg
Beschreibung
This antibody is predicted to react with canine and rat based on sequence homology. This antibody is tested in Peptide ELISA: antibody detection limit dilution 8,000.
Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. In all species, catecholamine synthesis is regulated by the interaction of TH with a cofactor, tetrahydrobiopterin (BH4). BH4 binds to the TH catalytic domain, resulting in enzymatic activity. Unlike TH in non-primate species, four human TH mRNA splice variants (hTH1-hTH4) have been isolated. These variants are identical in their catalytic domain, but differ in their N-terminal, regulatory domains. TH is also responsible for the conversion of L-tyrosine to L-dopa. TH plays a key role in the physiology of adrenergic neurons. The role of TH in the synthesis of catecholamine neurotransmitters suggests a correlation between the enzyme and a number of neuropathogenic diseases including: Parkinson's disease, schizophrenia, Segawa syndrome, and dystonia, as well as a variety of cardiovascular diseases.Spezifikation
Tyrosine Hydroxylase | |
Polyclonal | |
Unconjugated | |
TH | |
dystonia 14; DYT14; DYT5b; EC 1.14.16.2; HGNC:11782; Th; TH isoform 3; TH isoform a; th1; TH-4; The; TY3H; TYH; TYH antibody; Tyrosine 3-hydroxylase; tyrosine 3-monooxygenase; tyrosine hydroxylase | |
Goat | |
Ammonium sulfate precipitation | |
RUO | |
7054 | |
-20° C, Avoid Freeze/Thaw Cycles | |
Liquid |
Immunohistochemistry (PFA fixed) | |
0.5 mg/mL | |
TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3 | |
P07101 | |
TH | |
Synthetic peptide sequence (VQDELDTLAHAL) corresponding to the C-terminus amino acids of TH | |
100 μg | |
Primary | |
Human | |
Antibody | |
IgG |