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TSLP Monoclonal Antibody (eBio28F12 (28F12)), Functional Grade, eBioscience™, Invitrogen™
Rat Monoclonal Antibody
Marke: Affymetrix eBioscience 16-5491-025
Additional Details : Gewicht : 0.03000kg
Beschreibung
The MAb eBio28F12 reacts with and inhibits the bioactivity of mouse TSLP. Thymic Stromal-Derived Lymphopoetin (TSLP) was first identified in the tissue culture supernatant of a thymic stromal cell line as a growth factor capable of inducing proliferation and differentiation of pre-B cells. It was later found to be closely related to another stromal cytokine, IL-7, with which it shares overlapping functions. Along with its proliferative effects on B cells, TSLP induces dendritic cells to support the differentiation of naive T cells towards the Th2 lineage and may also be involved in the development of CD4^+CD25^+ regulatory T cells. The receptor for TSLP is heterodimeric and shares one subunit, IL-7Ralpha, with IL-7 and other members of the family, while the TSLPR subunit is unique to TSLP. TSLP expression can be induced by a variety of inflammatory cytokines and TLR ligands. Expression is regulated by NF-kappaB and has been detected in epithelial cells, stromal cells, and basophils. Elevated levels of TSLP are associated with asthma and atopic dermatitis, which are both Th2-mediated inflammatory conditions. It is believed that chronic overexpression of TSLP may result in increased sensitivity to allergens, resulting in susceptibility to these conditions.
TSLP Monoclonal antibody specifically detects TSLP in Mouse samples. It is validated for Functional Assay, NeutralizationSpezifikation
| TSLP | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with no preservative; pH 7.2 | |
| Q9JIE6 | |
| Rat | |
| 25 mg | |
| Primary | |
| Mouse | |
| Antibody | |
| IgG2a κ |
| Functional Assay, Neutralization | |
| eBio28F12 (28F12) | |
| Functional Grade | |
| TSLP | |
| Thymic stroma-derived lymphopoietin; Thymic stromal lymphopoietin; TSLP | |
| Affinity chromatography | |
| RUO | |
| 53603 | |
| 4° C | |
| Liquid |
For Research Use Only.