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R&D Systems™ Trametinib

Artikelnummer. 18746376
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18746376 10 mg 10 Milligramm
18755836 50 mg 50 Milligramm
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Artikelnummer. 18746376 Lieferant R&D Systems™ Lieferanten-Nr. 7709/10
  • ONLINE EXCLUSIVE PRICE
    181.21 CHF
    163.80 CHF / 10 Milligramm
    Sparen 17.41 CHF
    9% Rabatt
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Verfügbar ab: 19-11-2026
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Description

A Tocris product, part of R&D Systems. Potent and selective MEK inhibitor; orally bioavailable

Trametinib is a potent and selective MEK1 and MEK2 inhibitor (IC50 = 0.92 and 1.8 nM, respectively, in cell-free assays). In vitro, it inhibits the growth of human colorectal cancer cell lines expressing either B-RAF or K-RAF (IC50 values range from 0.48 to 36 nM). In vivo, it suppresses tumor growth of HT-29 and COLO205 xenografts in nude mice. Trametinib induces apoptosis. This compound is orally bioavailable.
TRUSTED_SUSTAINABILITY

Specifications

Chemischer Name oder Material N-[3-[3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2 H)-yl]phenyl]acetamide
CAS 871700-17-3
Menge 10 mg
Produktlinie Tocris
Ziel MEK Inhibitors
Summenformel C26H23FIN5O4
Reinheit 0.98
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