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TNF alpha Monoclonal Antibody (1F3F3D4), eBioscience™, Invitrogen™

Rat Monoclonal Antibody

124.00 CHF - 341.00 CHF

Spezifikation

Antigen TNF alpha
Klon 1F3F3D4
Konzentration 0.5 mg/mL
Anwendungen Immunostaining
Klassifikation Monoclonal
Mehr Spezifikationen ansehen

Produkte 2
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
15268067
Unterlagen ansehen Aktionsdetails
Affymetrix eBioscience
14-7325-81
50 μg
124.00 CHF
50 Mikrogramm
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Verfügbar ab: 08-05-2024
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15278067
Unterlagen ansehen Aktionsdetails
Affymetrix eBioscience
14-7325-85
500 μg
341.00 CHF
500 Mikrogramm
Alternative Produkte anzeigen
Sparen Sie bis zu 
»
Verfügbar ab: 08-05-2024
Sie sich ein, um den Lagerbestand zu sehen
Zum Warenkorb hinzufügen
 
Beschreibung

Beschreibung

Description: The 1F3F3D4 antibody reacts with mouse tumor necrosis factor-alpha (TNFaalpha), a 17 kDa cytokine produced by monocytes, macrophages, neutrophils, NK cells and CD4(+) T cells. Applications Reported: The 1F3F3D4 antibody has been reported for use in capture of mouse TNF alpha by ELISA and ELISPOT. Applications Tested: The 1F3F3D4 antibody has been tested as the capture antibody in a sandwich ELISA for analysis of mouse TNF alpha (Tumor Necrosis Factor alpha). A suitable range of concentrations of this antibody for ELISA capture is 1-4 μg/mL. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered.

TNF alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophage and bind to its receptors, TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF alpha is involved in the regulation of immune cells, cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. TNF alpha exists as a multimer of two, three, or five noncovalently linked units, but shows a single 17 kDa band following SDS-PAGE under non-reducing conditions. Knockout studies in mice also suggested the neuroprotective function of TNF alpha, and has been observed to causes tumor necrosis when injected into tumor-bearing mice. Other functions of TNF-alpha include its role in the immune response to bacterial, viral, parasitic and certain fungal infections, as well as its role in the necrosis of specific tumors. TNF alpha causes cytolysis or cytostasis of certain transformed cells, being synergistic with interferon-gamma in its cytotoxicity. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.
Spezifikation

Spezifikation

TNF alpha
0.5 mg/mL
Monoclonal
Liquid
RUO
PBS with 0.09% sodium azide; pH 7.2
APC1 protein; Cachectin; C-domain 1; C-domain 2; cTNF; DADB-70P7.1; DIF; ICD1; ICD2; Intracellular domain 1; Intracellular domain 2; N-terminal fragment; NTF; RATTNF; Tnf; TNF alpha; TNF superfamily; TNF a; TNF, macrophage-derived; TNF, monocyte-derived; TNFA; TNF-a; TNFalpha; TNF-alpha; Tnfsf1a; TNFSF2; TNFa; TNLG1F; Tumor necrosis factor; tumor necrosis factor (TNF superfamily, member 2); tumor necrosis factor alpha; tumor necrosis factor alpha (cachetin); tumor necrosis factor alpha precursor; tumor necrosis factor ligand 1F; tumor necrosis factor ligand superfamily member 2; Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form; tumor necrosis factor-alpha; tumor necrosis factor-alpha precursor; tumor-necrosis factor; tumour necrosis factor
Tnf
Primary
4° C
Tnf
1F3F3D4
Immunostaining
Unconjugated
Rat
Mouse
P06804
21926
IgM κ
Affinity chromatography
Antibody
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

Dokumentation

Product Certifications

For Research Use Only.