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TNF alpha Mouse anti-Human, Biotin, Clone: MAb11, eBioscience™

Mouse Monoclonal Antibody

Marke:  Affymetrix eBioscience 13-7349-81

Additional Details : Gewicht : 0.25000kg

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Artikelnummer. 15320070

  • 120.00 CHF / 50 Mikrogramm


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Beschreibung

Beschreibung

Description: The MAb11 antibody reacts with human tumor necrosis factor-alpha (TNF-alpha ), a 17 kDa cytokine produced by monocytes, macrophages, neutrophils, NK cells and CD4^+ T cells. TNF-alpha has cytolytic activity against a range of tumor cells and is important in immune regulation. TNF-alpha forms dimers and trimers and also exists as a 26 kDa membrane bound form. The MAb11 antibody is a neutralizing antibody. Applications Reported: The MAb11 antibody has been reported for use in detection of human TNF alpha by ELISA. Applications Tested: The MAb11 antibody has been tested as the detection antibody in a sandwich ELISA for analysis of human TNF-alpha (TNF-a, TNFa) in combination with the purified MAb1 (14-7348) antibody for capture and recombit human TNFa (14-8329) as the standard. A suitable range of concentrations of this antibody for ELISA detection is 0.5-2 µg/mL. A standard curve consisting of doubling dilutions of the recombit standard over the range of 1000 pg/mL - 8 pg/mL should be included in each ELISA plate. Filtration: 0.2 μm post-manufacturing filtered.

TNF alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophage and bind to its receptors, TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF alpha is involved in the regulation of immune cells, cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. TNF alpha exists as a multimer of two, three, or five noncovalently linked units, but shows a single 17 kDa band following SDS-PAGE under non-reducing conditions. Knockout studies in mice also suggested the neuroprotective function of TNF alpha, and has been observed to causes tumor necrosis when injected into tumor-bearing mice. Other functions of TNF-alpha include its role in the immune response to bacterial, viral, parasitic and certain fungal infections, as well as its role in the necrosis of specific tumors. TNF alpha causes cytolysis or cytostasis of certain transformed cells, being synergistic with interferon-gamma in its cytotoxicity. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.
Spezifikation

Spezifikation

TNF alpha
Monoclonal
0.5 mg/mL
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
P01375
DADB-70P7.1, DIF, TNF-alpha, TNFA, TNFSF2
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
ELISA
MAb11
Biotin
TNF
Liquid
TNF
IgG1, kappa
50 μg
4° C, store in dark, DO NOT FREEZE!
Primary
7124
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

For Research Use Only.