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TMEM38B Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

133.80 CHF - 381.34 CHF

Spezifikation

Antigen TMEM38B
Konzentration 0.38 mg/mL
Anwendungen Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Klassifikation Polyclonal
Konjugat Unconjugated
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Produkte 2
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
16839394
Unterlagen ansehen Aktionsdetails
Proteintech
19919-1-AP-20UL
20 μL
133.80 CHF
20 Mikroliter
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Verfügbar ab: 16-04-2024
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16829394
Unterlagen ansehen Aktionsdetails
Proteintech
19919-1-AP-150UL
150 μL
381.34 CHF
150 Mikroliter
Alternative Produkte anzeigen
Sparen Sie bis zu 
»
Verfügbar ab: 16-04-2024
Sie sich ein, um den Lagerbestand zu sehen
Zum Warenkorb hinzufügen
 
Beschreibung

Beschreibung

TMEM38A and TMEM38B are two recently identified trimeric intracellular cation (TRIC) channel subtypes. TMEM38B is expressed in most mammalian tissues, while TMEM38A is preferentially expressed in excitable tissues such as striated muscle and brain. Mice deficient in both TMEM38A and TMEM38B suffer embryonic cardiac failure; the cardiac myocytes display severe dysfunction in SR Ca2+ handling, weakened Ca2+ release, and reduced K+ permeability indicating that the TRIC cation channels are likely to act as counter-ion channels that function in synchronization with Ca2+ release from intracellular stores. Mice that were lacking only TMEM38B however, die shortly after birth due to respiratory failure and have lungs exhibiting severe histological defect and ultrastructural abnormalities in their alveolar type II epithelial cells, indicating that TMEM38B are essential for perinatal lung maturation. Other experiments have shown that TMEM38A and TMEM38B can act with junctophilin proteins to support efficient ryanodine receptor-mediated Ca2+ release in muscle cells.
Spezifikation

Spezifikation

TMEM38B
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Unconjugated
Rabbit
Human
Q9NVV0
55151
TMEM38B Fusion Protein Ag13835
Primary
-20°C
TMEM38B
0.38 mg/mL
Polyclonal
Liquid
RUO
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
C9orf87, D4Ertd89e, TMEM38B, transmembrane protein 38B, TRIC B, TRICB
TMEM38B
IgG
Antigen Affinity Chromatography
Antibody
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

Dokumentation

Product Certifications