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TIM3 Monoclonal Antibody (25F.1D6), Invitrogen™
Rat Monoclonal Antibody
Marke: Invitrogen MA517955
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Beschreibung
MA5-17955 targets TIM3 in FACS and IHC applications and shows reactivity with Mouse samples. The MA5-17955 immunogen is mouse T cell clone AE7 cells.
TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-dmain containing-3) is a 281 amino acid long, Type-1 Th1- specific cell surface glycoprotein expressed on terminally differentiated CD4+Th1 and CD8+Tc1 cells. TIM3 consists of an IgV-like domain, a mucin-like domain in the extracellular region, and a conserved Tyrosine phosphorylation motif in the cytoplasmic region. TIM3 is involved in macrophage activation and induction of autoimmune diseases. Further, TIM3 down-regulates aggressive Th1-mediated immune responses and facilitates in the development of immune tolerance. Pathological significance of TIM3 has been attributed to Experimental autoimmune encephalomyelitis (EAE), a Th-1 dependent autoimmune disease, and also enhances the severity of experimental autoimmune encephalomyelitis in mice.
Spezifikation
| TIM3 | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with 0.02% sodium azide | |
| Q8VIM0 | |
| Havcr2 | |
| Murine T cell clone AE7 cells | |
| 250 μg | |
| Primary | |
| Mouse | |
| Antibody | |
| IgG2a κ |
| Flow Cytometry, Immunohistochemistry | |
| 25F.1D6 | |
| Unconjugated | |
| Havcr2 | |
| CD366; FLJ14428; Havcr2; HAVcr-2; Hepatitis A virus cellular receptor 2; hepatitis A virus cellular receptor 2 homolog; kidney injury molecule-3; KIM-3; sCD366; soluble CD366; soluble TIM 3; T cell immunoglobulin mucin 3; T cell immunoglobulin mucin-3; T-cell immunoglobulin and mucin domain containing 3; T-cell immunoglobulin and mucin domain-containing protein 3; T-cell immunoglobulin mucin family member 3; T-cell immunoglobulin mucin receptor 3; T-cell membrane protein 3; Tim3; TIM-3; TIMD3; TIMD-3 | |
| Rat | |
| Protein G | |
| RUO | |
| 171285 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
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