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TCR beta Monoclonal Antibody (H57-597), Super Bright™ 600, eBioscience™, Invitrogen™
Armenian Hamster Monoclonal Antibody
384.00 CHF
Spezifikation
Antigen | TCR beta |
---|---|
Klon | H57-597 |
Konzentration | 0.2 mg/mL |
Anwendungen | Flow Cytometry |
Klassifikation | Monoclonal |
Beschreibung
Armenian Hamster Monoclonal Antibody
The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease (ref5). T Cell and TCR Diversity Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.Spezifikation
TCR beta | |
0.2 mg/mL | |
Monoclonal | |
Liquid | |
RUO | |
PBS with BSA and 0.09% sodium azide; pH 7.2 | |
Tcrb | |
Primary | |
4° C, store in dark, DO NOT FREEZE! | |
Tcrb |
H57-597 | |
Flow Cytometry | |
Super Bright 600 | |
Armenian Hamster | |
Mouse | |
21577 | |
IgG | |
Affinity chromatography | |
Antibody |