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TCR beta Monoclonal Antibody (H57-597), Functional Grade, eBioscience™, Invitrogen™

Armenian Hamster Monoclonal Antibody

83.00 CHF - 343.00 CHF

Spezifikation

Antigen TCR beta
Klon H57-597
Konzentration 1 mg/mL
Anwendungen Flow Cytometry, Functional Assay
Klassifikation Monoclonal
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Produkte 3
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
15228717
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Affymetrix eBioscience
16-5961-82
100 μg
204.00 CHF
100 Mikrogramm
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Verfügbar ab: 08-05-2024
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15218717
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Affymetrix eBioscience
16-5961-81
50 μg Dieser Artikel wurde eingestellt und ist leider nicht mehr verfügbar. Sehen Sie sich das Produkt an, um alternative Produktvorschläge zu sehen oder kontaktieren Sie unseren Technischen Support unter 056 618 41 11.
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15238717
Unterlagen ansehen Aktionsdetails
Affymetrix eBioscience
16-5961-85
500 μg Dieser Artikel wurde eingestellt und ist leider nicht mehr verfügbar. Sehen Sie sich das Produkt an, um alternative Produktvorschläge zu sehen oder kontaktieren Sie unseren Technischen Support unter 056 618 41 11.
N/A Alternative Produkte anzeigen
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Beschreibung

Beschreibung

Description: The H57-597 monoclonal antibody reacts with the beta chain of mouse TCR. TCR beta is expressed by thymocytes in a developmentally regulated manner and a majority of peripheral T cells. Crosslinking of the TCR complex with H57-597 induces activation and proliferation of T cells or apoptosis based on assay conditions. H57-597 is used as a phenotypic marker for TCR beta expressing T cells. Applications Reported: This H57-597 antibody has been reported for use in flow cytometric analysis. The H57-597 monoclonal antibody has also been reported for cross-linking the T cell receptor resulting in T cell activation, and for in vitro depletion. Applications Tested: The H57-597 antibody has been tested by flow cytometric analysis of mouse thymocytes and splenocytes. This can be used at less than or equal to 0.5 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Storage and handling: Use in a sterile environment. Filtration: 0.2 μm post-manufacturing filtered. Purity: Greater than 90%, as determined by SDS-PAGE. Endotoxin Level: Less than 0.001 ng/μg antibody, as determined by LAL assay. Aggregation: Less than 10%, as determined by HPLC.

The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease (ref5). T Cell and TCR Diversity Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.
Spezifikation

Spezifikation

TCR beta
1 mg/mL
Monoclonal
Liquid
RUO
PBS with no preservative; pH 7.2
Tcrb
Primary
4° C
Tcrb
H57-597
Flow Cytometry, Functional Assay
Functional Grade
Armenian Hamster
Mouse
21577
IgG
Affinity chromatography
Antibody
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

Dokumentation

Product Certifications

For Research Use Only.