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TAZ Mouse anti-Human, Mouse, Rat, Clone: 2A12A10, Proteintech

Mouse Monoclonal Antibody

Marke:  Proteintech 66500-1-IG-150UL

Additional Details : Gewicht : 0.00010kg

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Artikelnummer. 16838435

  • 351.68 CHF / 150 Mikroliter

Verfügbar ab: 28-06-2022
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Beschreibung

Beschreibung

WW domain-containing transcription regulator protein 1 (WWTR1) is a transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor supression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1. In turn, MOB1 phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. WWTR1 regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. WWTR1 also regulates embryonic stem-cell self-renewal and promotes cell proliferation and epithelial-mesenchymal transition.
Spezifikation

Spezifikation

TAZ
Monoclonal
1 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Q9EPK5, Q9GZV5
Wwtr1
TAZ Fusion Protein Ag13330
150 μL
Primary
Human, Mouse, Rat
Liquid
Immunohistochemistry (Paraffin), Western Blot
2A12A10
Unconjugated
WWTR1
TAZ, WWTR1
Mouse
Protein G
RUO
25937, 295062, 97064
Antibody
IgG1
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation
Zertifikate
Sonderangebote

Sonderangebote