Tara Polyclonal Antibody, Invitrogen™

Beschreibung

Immunogen sequence: EIGALMRQAE EREHTLRRCQ QEGQELLRHN QELHGRLSEE IDQLRGFIAS QGMGNGCGRS NERSSCELEV LLRVKENELQ YLKKEVQCLR DELQMMQKDK RFTSGKYQDV YVELSHIKTR SEREIEQLKE HLRL Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 91%.

This gene encodes a protein with an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. The protein interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility and cell growth. The protein also associates with F-actin and stabilizes F-actin structures. Mutations in this gene have been associated with a form of autosomal recessive nonsyndromic deafness. Multiple alternatively spliced transcript variants that would encode different isoforms have been found for this gene, however some transcripts may be subject to nonsense-mediated decay (NMD).