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TAB2 Monoclonal Antibody (G.188.0), Invitrogen™
Rabbit Monoclonal Antibody
Marke: Invitrogen MA514818
Additional Details : Gewicht : 0.01000kg
Beschreibung
It is not recommended to aliquot this antibody.
TAB2 is an activator of MAP3K7/TAK1, which is required for the IL-1 induced activation NF-kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKL through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Recent experiments have shown that TAB2 and the related protein TAB3 constitutively interact with the autophagy mediator Beclin-1; upon induction of autophagy, these proteins dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibit autophagy, while their depletion triggers it, suggesting that TAB2 and TAB3 act as a control point for autophagy.Spezifikation
TAB2 | |
Monoclonal | |
Unconjugated | |
Tab2 | |
1110030N06Rik; A530078N03Rik; CHTD2; FLJ21885; KIAA0733; MAP3K7IP2; mitogen activated protein kinase kinase kinase 7 interacting protein 2; mitogen-activated protein kinase kinase kinase 7 interacting protein 2; mitogen-activated protein kinase kinase kinase 7-interacting protein 2; mKIAA0733; OTTHUMP00000017388; Tab2; TAB-2; Tak1 binding protein 2; TAK1-binding protein 2; TGF-beta activated kinase 1 (MAP3K7) binding protein 2; TGF-beta activated kinase 1/MAP3K7 binding protein 2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; TGF-beta-activated kinase 1-binding protein 2 | |
Rabbit | |
Affinity chromatography | |
RUO | |
23118, 308267, 68652 | |
-20°C | |
Liquid |
Immunoprecipitation, Western Blot | |
G.188.0 | |
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and <0.02% sodium azide; pH 7.5 | |
Q5U303, Q99K90, Q9NYJ8 | |
Tab2 | |
Synthetic peptide corresponding to residues surrounding Leu330 of human TAB2 | |
100 μL | |
Primary | |
Human, Mouse, Non-human Primate, Rat | |
Antibody | |
IgG |