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SURVIVIN Mouse anti-Human, Clone: 3B9H7, Proteintech

Mouse Monoclonal Antibody

133.80 CHF - 381.34 CHF

Spezifikation

Antigen SURVIVIN
Klon 3B9H7
Konzentration 1 mg/mL
Anwendungen Western Blot
Klassifikation Monoclonal
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Produkte 2
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
16848425
Unterlagen ansehen Aktionsdetails
Proteintech
66495-1-IG-20UL
20 μL
133.80 CHF
20 Mikroliter
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Verfügbar ab: 17-04-2024
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16838425
Unterlagen ansehen Aktionsdetails
Proteintech
66495-1-IG-150UL
150 μL
381.34 CHF
150 Mikroliter
Alternative Produkte anzeigen
Sparen Sie bis zu 
»
Verfügbar ab: 17-04-2024
Sie sich ein, um den Lagerbestand zu sehen
Zum Warenkorb hinzufügen
 
Beschreibung

Beschreibung

Survivin (IAP4) is the smallest member of the Inhibitors of Apoptosis Protein (IAP) gene family. The IAPs are involved in multiple cell functions such as cell signaling, cell division, metabolism, and exhibits differential expression in nearly all human cancers, but not in most normal tissues. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but the Survivin gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors yet low in adult tissues. Antisense transcripts are involved in the regulation of survivin′s gene expression. Survivin is expressed in the G2/M phase of the cell cycle in a cycle-regulated manner. At the beginning of mitosis, survivin associates with microtubules of the mitotic spindle in a specific and saturable reaction that is regulated by microtubule dynamics. Disruption of survivin-microtubule interactions results in loss of survivin′s anti-apoptosis function and increased caspase-3 activity, a mechanism involved in cell death, during mitosis. Survivin may counteract a default induction of apoptosis in G2/M phase. Survivin is also abundantly expressed in brain tissues (astrocytes and some neurons) of adult rats following traumatic brain injury. Survivin has been found co-expressed with NeuN (mature neuronal marker) and PCNA (a cell cycle protein). Survivin might affect regulation of neural cell proliferative responses after brain injury. At least four transcript variants encoding distinct isoforms have been found for this gene, but the full-length natures of only three of them have been determined. The overexpression of survivin in cancer may overcome this apoptotic checkpoint and favor aberrant progression of transformed cells through mitosis.
Spezifikation

Spezifikation

SURVIVIN
1 mg/mL
Monoclonal
Liquid
RUO
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
API4, Apoptosis inhibitor 4, Apoptosis inhibitor survivin, BIRC5, EPR 1, IAP4, SURVIVIN
BIRC5
IgG1
Protein A
Antibody
3B9H7
Western Blot
Unconjugated
Mouse
Human
O15392
332
SURVIVIN Fusion Protein Ag20958
Primary
-20°C
BIRC5
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SDS
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