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SMC1 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Marke: Invitrogen PA529122
Additional Details : Gewicht : 0.01000kg
Beschreibung
Recommended positive controls: 293T, A431, H1299, HeLa, HepG2, Molt-4, Raji. Predicted reactivity: Mouse (99%), Rat (98%), Zebrafish (84%), Xenopus laevis (91%), Chicken (94%), Bovine (99%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Structural Maintenance of Chromosomes (SMC) family proteins play critical roles in various nuclear events that require structural changes of chromosomes, including mitotic chromosome organization, DNA recombination and repair and global transcriptional repression. The chromo proteins are conserved in eukaryotes and lead to mitotic chromosome segregatior defects. This suggests a critical function of SMC family proteins in mitotic chromosome dynamics. SMC1 and SMC3 form a heterodimeric complex required for metaphase progression in mitotic cells. Specifically this SMC1/SMC3 complex is responsible for sister chromatid cohesion during metaphase. Mutations in the gene can lead to Cornelia de Lange syndrome 2.Spezifikation
SMC1 | |
Polyclonal | |
Unconjugated | |
SMC1A | |
14S cohesin SMC1 subunit; 5830426I24Rik; CDLS2; chromosome segregation protein SmcB; DKFZp686L19178; DXhXs423e; DXS423E; KIAA0178; MGC138332; mitosis-specific chromosome segregation protein like protein beta; mKIAA0178; RP6-29D12.1; Sb1.8; segregation of mitotic chromosomes 1; segregation of mitotic chromosomes b; segregation of mitotic chromosomes-like 1; SM1A; SMC; SMC (segregation of mitotic chromosomes 1)-like 1; SMC protein; SMC protein 1A; SMC protein 1B; SMC1; SMC1 (structural maintenance of chromosomes 1, yeast)-like 1; SMC1 protein; SMC1 protein cohesin subunit; SMC1 structural maintenance of chromosomes 1-like 1; SMC1 structural maintenance of chromosomes 1-like 2; Smc1a; SMC-1A; smc1a.L; smc1aa; Smc1alpha; SMC-1-alpha; SMC1alpha protein; Smc1b; SMC-1B; SMC1BETA; SMC-1-beta; SMC1L1; Smc1l2; Smcb; SMC-like 1; SMC-protein; structural maintenace of chromosomes 1B; structural maintenance of chromosomes 1; structural maintenance of chromosomes 1 like 1; structural maintenance of c | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
27127, 8243 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot | |
1 mg/mL | |
0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7 | |
Q14683, Q8NDV3 | |
SMC1A, SMC1B | |
Recombinant fragment corresponding to a region within amino acids 719 and 1019 of Human SMC1A | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |