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ACROBiosystems Rat PD-1 / PDCD1 Protein, His Tag
378.31 CHF - 2522.00 CHF
Spezifikation
Zugriffsnummer | NP_001100397.1 |
---|---|
Molekulargewicht | 18.1 kDa |
Quelle | Rat PD-1, His Tag (PD1-R52H2) is expressed from human 293 cells (HEK293). It contains AA Leu 25 - Gln 167 (Accession # NP_001100397.1). |
Immunogen | Leu 25 - Gln 167 |
Lagerungsbedingungen | -20°C |
Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
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Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
15807507
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ACROBiosystems
PD1-R52H2-100UG |
100 μg |
378.31 CHF
100 Mikrogramm |
Verfügbar ab: 16-05-2024
Loggen Sie sich ein, um den Lagerbestand zu sehen |
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15817507
|
ACROBiosystems
PD1-R52H2-1MG |
1 mg |
2522.00 CHF
1 Milligramm |
Verfügbar ab: 16-05-2024
Loggen Sie sich ein, um den Lagerbestand zu sehen |
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Beschreibung
Programmed cell death protein 1 (PD-1) is also known as CD279 and PDCD1, is a type I membrane protein and is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 is expressed on the surface of activated T cells, B cells, macrophages, myeloid cells and a subset of thymocytes. PD-1 has two ligands, PD-L1 and PD-L2, which are members of the B7 family. PD-L1 is expressed on almost all murine tumor cell lines, including PA1 myeloma, P815 mastocytoma, and B16 melanoma upon treatment with IFN-γ. PD-L2 expression is more restricted and is expressed mainly by DCs and a few tumor lines. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. In vitro, treatment of anti-CD3 stimulated T cells with PD-L1-Ig results in reduced T cell proliferation and IFN-γ secretion. Monoclonal antibodies targeting PD-1 that boost the immune system are being developed for the treatment of cancer.
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 18.1 kDa. The protein migrates as 30-44 kDa under reducing (R) condition (SDS-PAGE).Spezifikation
NP_001100397.1 | |
Rat PD-1, His Tag (PD1-R52H2) is expressed from human 293 cells (HEK293). It contains AA Leu 25 - Gln 167 (Accession # NP_001100397.1). | |
-20°C | |
PD-1 | |
Rat | |
PBS, pH7.4 | |
HEK293 | |
Immune Checkpoint Proteins |
18.1 kDa | |
Leu 25 - Gln 167 | |
PDCD1,PD1,CD279,SLEB2 | |
Unconjugated | |
His Tag | |
Less than 1.0 EU / μg by the LAL method. | |
Powder | |
>95% as determined by SDS-PAGE |