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ACROBiosystems Rat PD-1 / PDCD1 Protein, His Tag

Marke:  ACROBiosystems PD1-R52H2-1MG

Additional Details : Gewicht : 0.00001kg

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Artikelnummer. 15817507

  • 2072.64 CHF / 1 Milligramm


Verfügbar ab
28-05-2021
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Beschreibung

Beschreibung

Programmed cell death protein 1 (PD-1) is also known as CD279 and PDCD1, is a type I membrane protein and is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 is expressed on the surface of activated T cells, B cells, macrophages, myeloid cells and a subset of thymocytes. PD-1 has two ligands, PD-L1 and PD-L2, which are members of the B7 family. PD-L1 is expressed on almost all murine tumor cell lines, including PA1 myeloma, P815 mastocytoma, and B16 melanoma upon treatment with IFN-γ. PD-L2 expression is more restricted and is expressed mainly by DCs and a few tumor lines. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. In vitro, treatment of anti-CD3 stimulated T cells with PD-L1-Ig results in reduced T cell proliferation and IFN-γ secretion. Monoclonal antibodies targeting PD-1 that boost the immune system are being developed for the treatment of cancer.

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 18.1 kDa. The protein migrates as 30-44 kDa under reducing (R) condition (SDS-PAGE).
Spezifikation

Spezifikation

NP_001100397.1
HEK293
Rat
18.1 kDa
1 mg
Leu 25 - Gln 167
PDCD1,PD1,CD279,SLEB2
Unconjugated
PBS, pH7.4
Less than 1.0 EU / µg by the LAL method.
Immune Checkpoint Proteins
Powder
>95% as determined by SDS-PAGE
Rat PD-1, His Tag (PD1-R52H2) is expressed from human 293 cells (HEK293). It contains AA Leu 25 - Gln 167 (Accession # NP_001100397.1).
-20°C
PD-1
His Tag
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation