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ACROBiosystems Rat CTLA-4 / CD152 Protein, Fc Tag

Marke:  ACROBiosystems CT4-R5259-100UG

Additional Details : Gewicht : 0.00001kg

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Artikelnummer. 15826537

  • 287.87 CHF / 100 Mikrogramm


Verfügbar ab
28-05-2021
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Beschreibung

Beschreibung

CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system. CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function. Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis.

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 40.2 kDa. The protein migrates as 50-55 kDa under reducing (R) condition (SDS-PAGE).
Spezifikation

Spezifikation

Less than 1.0 EU / µg by the LAL method.
Immune Checkpoint Proteins
Powder
>95% as determined by SDS-PAGE
Rat CTLA-4, Fc Tag (CT4-R5259) is expressed from human 293 cells (HEK293). It contains AA Ile 38 - Asp 161 (Accession # Q62859).
-20°C
CTLA-4
Fc Tag
HEK293
Rat
40.2 kDa
100 µg
Ile 38 - Asp 161
CTLA4,CD152
Unconjugated
Tris with Glycine, Arginine and NaCl, pH7.5
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Sicherheitsdatenblatt (SDS)
Dokumentation