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ARRB1 (phospho S412), Rabbit anti-Human, Mouse, Polyclonal Antibody, Abnova™
Beschreibung
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described, however, their exact functions are not known. [provided by RefSeq
Spezifikation
Spezifikation
| Antigen | ARRB1 |
| Anwendungen | Immunohistochemistry (PFA fixed), Western Blot |
| Klassifikation | Polyclonal |
| Konjugat | Unconjugated |
| Beschreibung | Rabbit polyclonal antibody raised against synthetic phosphopeptide of human ARRB1. |
| Verdünnung | Immunohistochemistry (1:50∼1:100) Western Blot (1:500∼1:1000) The optimal working dilution should be determined by the end user. |
| Zusammensetzung | In PBS (without mg2+ and Ca2+), 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide) |
| Gen | ARRB1 |
| Gen-Zugriffsnummer | P49407 |
| Gen-Alias | ARB1/ARR1 |
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For Research Use Only
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