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Tocris Bioscience™ TC-G 1008
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Menge:
10 mg
50 mg
Packungsgröße:
10 Milligramm
50 Milligramm
Beschreibung
Potent and selective GPR39 agonist (EC50 values are 0.4 and 0.8 nM for rat and human receptors respectively). Selective over a panel of kinases (IC50s > 10 μM) and displays minimal binding affinity for ghrelin and neurotensin-1 receptors (IC50s > 30 μM). Increases GLP-1 levels in vitro and in vivo. Reduces TNF-α-induced oxidative stress, mitochondrial dysfunction, cytokine expression and secretion of MMPs in fibroblast-like synoviocytes (FLS). Orally bioavailable.
TC-G 1008 is a potent and selective GPR39 agonist (EC50 values are 0.4 and 0.8 nM for rat and human receptors respectively). Selective over a panel of kinases (IC50s > 10 μM) and displays minimal binding affinity for ghrelin and neurotensin-1 receptors (IC50s > 30 μM). Increases GLP-1 levels in vitro and in vivo. Reduces TNF-α-induced oxidative stress, mitochondrial dysfunction, cytokine expression and secretion of MMPs in fibroblast-like synoviocytes (FLS). Orally bioavailable.
Spezifikation
Spezifikation
| Chemischer Name oder Material | TC-G 1008 |
| CAS | 1621175-65-2 |
| Synonym | N-[3-Chloro-4-[[[2-(methylamino)-6-(2-pyridinyl)-4-pyrimidinyl]amino]methyl]phenyl]methanesulfonate |
| Menge | 50 mg |
| Löslichkeit | Soluble to 20mM in DMSO |
| Summenformel | C18H19ClN6O2S |
| Formelmasse | 418.9 |
| Physikalische Form | Fest |
| Produkttyp | Bioactive Small Molecule |
| Reinheit | >98% |
Research Use Only. Not For Human or Veterinary Use
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