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PTPN2 Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marke:  Proteintech 11214-1-AP-150UL

Additional Details : Gewicht : 0.00010kg

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Artikelnummer. 16838143

  • 351.68 CHF / 150 Mikroliter

Verfügbar ab: 01-07-2022
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Beschreibung

Beschreibung

T-cell protein tyrosine phosphatase (TC-PTP), also known as PTPT and PTPN2, is an enzyme that removes phosphate groups covalently attached to tyrosine residues in proteins. This enzyme has two C-terminal end splice variants with distinctly different subcellular localizations. The shorter 45 kilodalton isoform is exclusively nuclear in resting cells, but redistrubutes to the cytosol upon stimulation with growth factors and cellular stress. The longer 48 kilodalton isoform is exclusively found in the endoplasmic reticulum 3 and seems to have distinctly different physiologic substrates from the smaller isoform. Although found in many cell types and tissues, TC-PTP is particularly prominent in hemopoietic cell types. Knockout mice lacking TC-PTP are born viable but die 3 to 5 weeks after birth of erythropoietic and lymphopoietic deficits 7 , indicating a critical role for TC-PTP in bone marrow maturation. TC-PTP will dephosphorylate a wide range of phosphoproteins, such as p52 Shc 6 and receptors for EGF 1 , Insulin 8 and growth hormone.
Spezifikation

Spezifikation

PTPN2
Polyclonal
Unconjugated
PTPN2
PTPN2, PTPT, TC PTP, TCELLPTP, TCPTP
Rabbit
Antigen Affinity Chromatography
RUO
19255, 5771
Antibody
IgG
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
0.31 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
P17706, Q06180
PTPN2
PTPN2 Fusion Protein Ag1709
150 μL
Primary
Human, Mouse
Liquid
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation
Zertifikate
Sonderangebote

Sonderangebote