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Podoplanin Monoclonal Antibody (eBio8.1.1 (8.1.1)), Biotin, eBioscience™, Invitrogen™

Syrian Hamster Monoclonal Antibody

242.00 CHF

Spezifikation

Antigen Podoplanin
Klon eBio8.1.1 (8.1.1)
Konzentration 0.5 mg/mL
Anwendungen Flow Cytometry, Immunohistochemistry
Klassifikation Monoclonal
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Produkte 1
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
15289829
Unterlagen ansehen Aktionsdetails
Affymetrix eBioscience
13-5381-82
100 μg
242.00 CHF
100 Mikrogramm
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Beschreibung

Beschreibung

Description: The 8.1.1 monoclonal antibody reacts with mouse podoplanin (T1a, gp38, aggrus), a 43 kDa transmembrane glycoprotein, named for its expression in kidney glomerular epithelial cells (podocytes). In addition, Podoplanin is expressed in epithelial and mesothelial cells such as intestinal epithelium, alveolar type I cells, podocytes, and mesothelium of the visceral peritoneum. It was also shown to be a potent marker for lymphatic endothelium. Podoplanin is also expressed by subcapsular epithelial cells of the murine thymus. Mice deficient in Podoplanin die at birth because of a respiratory defect and congenital lymphedema due to a failure in lymphatic pattern formation. Applications Reported: This eBio8.1.1 (8.1.1) antibody has been reported for use in flow cytometric analysis and immunohistochemistry. Applications Tested: This eBio8.1.1 (8.1.1) antibody has been tested by flow cytometric analysis of TE-71 cells. This can be used at less than or equal to 0.25 μg per million cells in a 100 μL total staining volume. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Filtration: 0.2 μm post-manufacturing filtered.

Podoplanin (PDPN, T1A, gp38, Aggrus) is a mucin type-1 glycoprotein with a 40-43 kDa molecular weight. Podoplanin is expressed in many tumors and normal cells, especially lymphatic epithelial cells and follicular DCs. Podoplanin localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells. As a regulator of the lymphatic endothelium, podoplanin probably plays a role in maintaining the unique shape of podocytes. Podoplanin appears to serve as a ligand for CLEC-2 and expression is positively correlated with tumors expressing greater invasive and metastatic potential. Podoplanin is directly involved in cell migration, aids metastases formation and tumor cell invasion of tissue. Further, it has also been determined that podoplanin expression is induced through Src activation of Cas and, recently, there are indications of podoplanin presence on Th17 cells. Initial studies below indicate the presence of podoplanin on a small but distinct population of CD4+ cells from human PBMC. Dysfunction of the podoplanin protein has been linked to diseases such as lymphangioma and subglottis neoplasm. Podoplanin has also been proposed as a marker for lung injury due to the physiological function of the protein.
Spezifikation

Spezifikation

Podoplanin
0.5 mg/mL
Monoclonal
Liquid
RUO
Q62011
PDPN
Primary
4° C, store in dark, DO NOT FREEZE!
eBio8.1.1 (8.1.1)
Flow Cytometry, Immunohistochemistry
Biotin
Syrian Hamster
Mouse
14726
IgG
Affinity chromatography
Antibody
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Sicherheitsdatenblatt (SDS)
Dokumentation

Dokumentation

Product Certifications

For Research Use Only.