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PLSCR1 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Marke: Invitrogen PA521649
Additional Details : Gewicht : 0.01000kg
Beschreibung
Recommended positive controls: 293T, A431, H1299, HeLaS3, HepG2, Molt-4. Predicted reactivity: Rhesus Monkey (96%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
The calcium-dependent plasma membrane protein phospholipid scramblase 1 (PLSCR1) contributes to the transbilayer movement of phosphatidylserine and other membrane phospholipids upon influx of calcium into the cytosol. This movement results in plasma membrane phospholipid remodelling and surface exposure of phosphatidylserine in injured or apoptotic cells, which leads to cell death. Interferons and other cytokines induce expression of PLSCR1, implying that PLSCR1 also functions in cytokine signaling pathways. EGF stilmulation results in tyrosine phosphorylation of PLSCR1 on tyrosines 69 and 74, which allows it to interact with Shc, and thereby connecting Src kinase activation to stimulation of the EGF receptor.Spezifikation
| PLSCR1 | |
| Polyclonal | |
| Unconjugated | |
| PLSCR1 | |
| ca(2+)-dependent phospholipid scramblase 1; Erythrocyte phospholipid scramblase; MmTRA1a; MmTRA1b; NOR1; Phospholipid scramblase 1; phospholipid scramblase 2; PL scramblase 1; Plscr1; Tra1; Tra1a; Tra1b; transplantability-associated protein 1; Tras1; Tras2 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 5359 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot | |
| 0.52 mg/mL | |
| 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7 | |
| O15162 | |
| PLSCR1 | |
| Recombinant fragment corresponding to a region within amino acids 1 and 286 of Scramblase1 (Uniprot ID#O15162) | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |