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Phospho-MCL1 (Ser159) Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Marke: Invitrogen PA538675
Additional Details : Gewicht : 0.00900kg
Beschreibung
Mcl-1 (Myeloid cell leukemia-1) is a member of the bcl-2 family. The carboxy terminal of Mcl-1 and bcl-2 share significant sequence homology. Expression of Mcl-1 is increased upon exposure of ML-1 cells to various types of DNA damaging agents (e.g. ionizing radiation, ultraviolet radiation, and alkylating drugs) along with increases in GADD45 and Bax and a decrease in bcl-2. Enhanced expression of Mcl-1, prominently associated with mitochondria, complements the continued expression of bcl-2 in ML-1 cells undergoing differentiation. Like bcl-2, Mcl-1 has the capacity to promote cell viability under conditions that otherwise cause apoptosis.Spezifikation
| Phospho-MCL1 (Ser159) | |
| Polyclonal | |
| Unconjugated | |
| MCL1 | |
| BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT, bcl-2-like protein 3, bcl-2-related protein EAT/mcl1, induced myeloid leukemia cell differentiation protein Mcl-1, myeloid cell leukemia ES | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 17210, 4170 | |
| -20°C | |
| Liquid |
| Peptide ELISA, Immunofluorescence | |
| 1 mg/mL | |
| Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4 | |
| Q07820, P97287 | |
| MCL1 | |
| A synthetic phosphopeptide derived from human MCL1 around the phosphorylation site of Ser159 (D-G-SP-L-P) | |
| 100 μg | |
| Primary | |
| Human, Mouse | |
| Antibody | |
| IgG |