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Phospho-B-Raf (Ser445) Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Marke: Invitrogen PA517535
Additional Details : Gewicht : 0.01000kg
Beschreibung
It is not recommended to aliquot this antibody.
BRAF is involved in the transduction of mitogenic signals from the cell membrane to the nucleus. It is activated by somatic point mutation in human cancer, and is thought to play a role in the postsynaptic responses of hippocampal neuron. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in B-Raf have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for B-Raf.Spezifikation
| Phospho-B-Raf (Ser445) | |
| Polyclonal | |
| Unconjugated | |
| BRAF | |
| 94 kDa B-raf protein; 9930012E13Rik; AA120551; AA387315; AA473386; Braf; B-raf; B-raf protein; B-raf protein isoform 1; B-raf protein isoform 2; B-Raf proto-oncogene serine/threonine-protein kinase; B-Raf proto-oncogene serine/threonine-protein kinase (p94); B-Raf proto-oncogene, serine/threonine kinase; Braf transforming gene; BRAF1; B-RAF1; Braf2; Braf-2; C230098H17; C87398; C-RMIL; D6Ertd631e; FLJ95109; MGC126806; murine sarcoma viral (v-raf) oncogene homolog B1; NS7; p94; Proto-oncogene B-Raf; proto-oncogene c-Rmil; RAFB1; RMIL; rmil serine/threonine-protein kinase; serine/threonine kinase; serine/threonine-protein kinase B-raf; Serine/threonine-protein kinase Rmil; v-raf murine sarcoma viral oncogene homolog B; v-raf murine sarcoma viral oncogene homolog B1 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 109880, 114486, 396239, 475526, 673 | |
| -20°C | |
| Liquid |
| Western Blot | |
| 4 μg/mL | |
| 0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5 | |
| P15056, P28028, Q04982 | |
| BRAF | |
| Phospho synthetic peptide corresponding to residues surrounding serine 445 of human B-Raf | |
| 100 μL | |
| Primary | |
| Canine, Chicken, Human, Mouse, Non-human Primate, Rat | |
| Antibody | |
| IgG |