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PDLIM1/CLP36 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marke:  Proteintech 11674-1-AP-20UL

Additional Details : Gewicht : 0.00010kg

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Artikelnummer. 16838913

  • 131.19 CHF / 20 Mikroliter

Verfügbar ab: 28-06-2022
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Beschreibung

Beschreibung

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. A distinctive feature of TBP is a long string of glutamines in the N-terminal. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. Mutations that expand the number of CAG repeats encoding this polyglutamine tract, and thus increase the length of the polyglutamine string, are associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease.
Spezifikation

Spezifikation

PDLIM1/CLP36
Polyclonal
Unconjugated
PDLIM1
CLIM1, CLP 36, CLP36, Elfin, hCLIM1, LIM domain protein CLP 36, PDLIM1, PDZ and LIM domain 1, PDZ and LIM domain protein 1
Rabbit
Antigen Affinity Chromatography
RUO
54132, 54133, 9124
Antibody
IgG
Immunofluorescence, Immunoprecipitation, Flow Cytometry, Immunohistochemistry (Paraffin), Immunocytochemistry
0.6 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
O00151, O70400, P52944
Pdlim1
PDLIM1/CLP36 Fusion Protein Ag2274
20 μL
Primary
Mouse, Rat, Human
Liquid
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation
Zertifikate
Sonderangebote

Sonderangebote