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p35 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marke:  Proteintech 18346-1-AP-20UL

Additional Details : Gewicht : 0.00010kg

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Artikelnummer. 16838434

  • 131.19 CHF / 20 Mikroliter

Verfügbar ab: 28-06-2022
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Beschreibung

Beschreibung

The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer′s disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer′s disease.
Spezifikation

Spezifikation

p35
Polyclonal
Unconjugated
CDK5R1
CDK5 activator 1, CDK5P35, CDK5R, CDK5R1, NCK5A, p23, p25, p35, p35nck5a, TPKII regulatory subunit
Rabbit
Antigen Affinity Chromatography
RUO
116671, 12569, 8851
Antibody
IgG
Western Blot, Immunoprecipitation
0.22 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
P61809, P61810, Q15078
CDK5R1
p35 Fusion Protein Ag13152
20 μL
Primary
Rat, Human, Mouse
Liquid
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation
Zertifikate
Sonderangebote

Sonderangebote