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Invitrogen™ Nhe-1 Polyclonal Antibody
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Artikelnummer. 15975595
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Menge:
100 μg
Packungsgröße:
100 Mikrogramm
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15975595 100 μg 100 Mikrogramm
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Artikelnummer. 15975595 Lieferant Invitrogen™ Lieferanten-Nr. PA580033

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Beschreibung

Rabbit Polyclonal Antibody

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: rat PC-12 whole cell, human MCF-7 whole cell. IHC: rat kidney tissue, human mammary cancer tissue, mouse kidney tissue.

The Na+/H+ antiporter (Nhe-1) is a ubiquitous membrane-bound enzyme involved in pH regulation of vertebrate cells and is specifically inhibited by the diuretic drug amiloride and activated by a variety of signals including growth factors, mitogens, neurotransmitters, and tumor promoters. Nhe-1 acts as an anchor for actin filaments to control the integrity of the cortical cytoskeleton. This occurs through a previously unrecognized structural link between Nhe-1 and the actin-binding proteins ezrin, radixin, and moesin, collectively referred to as ERM proteins. A structural role for Nhe-1 has been proposed in regulating the cortical cytoskeleton that is independent of its function as an ion exchanger. It is also thought that Nhe-1 play a role in hypertension. At least two isoforms of Nhe-1 are known to exist.
TRUSTED_SUSTAINABILITY

Spezifikation

Antigen Nhe-1
Anwendungen Immunohistochemistry (Paraffin), Western Blot
Klassifikation Polyclonal
Konzentration 500 μg/mL
Konjugat Unconjugated
Zusammensetzung PBS with 5mg BSA and 0.05mg sodium azide
Gen SLC9A1
Gen-Zugriffsnummer P19634, P26431, Q61165
Gen-Alias Apnh; APNH1; AW554487; LIKNS; Mir5122; mir-5122; Na(+)/H(+) antiporter, amiloride-sensitive; Na(+)/H(+) exchanger 1; Na+/H+ antiporter; Na+/H+, amiloride sensitive; Na-Li countertransporter; Nhe1; NHE-1; PPP1R143; protein phosphatase 1, regulatory subunit 143; SLC9A1; slow-wave epilepsy; sodium/hydrogen exchanger 1; Solute carrier family 9 (sodium/hydrogen exchanger 1), antiporter, Na+/H+, (amiloride sensitive); solute carrier family 9 (sodium/hydrogen exchanger), isoform 1 (antiporter, Na+/H+, amiloride sensitive); solute carrier family 9 (sodium/hydrogen exchanger), member 1; solute carrier family 9 (sodium/hydrogen exchanger), member 1 (antiporter, Na+/H+, amiloride sensitive); solute carrier family 9 member 1; solute carrier family 9 member A1; solute carrier family 9, member 1; solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1; swe
Gensymbole SLC9A1
Wirtsspezies Rabbit
Immunogen E.coli-derived human SLC9A1 recombinant protein (Position: H543-Q815).
Reinigungsverfahren Antigen affinity chromatography
Menge 100 μg
Regulatorischer Status RUO
Primär oder sekundär Primary
Gen-ID (Entrez) 20544, 24782, 6548
Zielspezies Human, Mouse, Rat
Inhalt und Lagerung -20°C
Produkttyp Antibody
Form Lyophilized
Isotype IgG
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