missing translation for 'onlineSavingsMsg'
Learn More

og Mouse anti-Human, Clone: hog.2, eBioscience™

Mouse Monoclonal Antibody

Marke:  Affymetrix eBioscience 14-5768-82

Additional Details : Gewicht : 0.01000kg

 Lernen Sie weitere Varianten dieses

Artikelnummer. 15227457

  • 409.00 CHF / 100 Mikrogramm


Geschätzter Ausliefertermin
von Anbieter 06-08-2020
Zum Warenkorb hinzufügen

Beschreibung

Beschreibung

It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered. NANOG (og homeobox) is a divergent homeodomain protein that directs pluripotency and differentiation of undifferentiated embryonic stem cells. NANOG mRNA is present in pluripotent mouse and human cell lines, and absent from differentiated cells. Human NANOG protein shares 52% overall amino acid identity with the mouse protein, and 85% identity in the homeodomain. Human NANOG maps to gene locus 12p13.31, while the mouse NANOG maps to gene loci 6 F2. Murine embryonic NANOG expression is detected in the inner cell mass of the blastocyst. Research studies have shown that high levels of human NANOG expression in the undifferentiated N-Tera embryonal carcinoma cell line. Further, NANOG is a transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. The role of NANOG in embryonic development suggested that it might be useful in the creation of stem cells that might be useful in cell replacement therapies in the treatment of several degenerative diseases. Artificial stem cells, termed induced pluripotent stem (iPS) cells, can be created by expressing POU5F1 (also known as Oct-4), another germline-specific transcription factor, and the transcription factors Sox2, Klf4 and Lin28 along with c-Myc in mouse fibroblasts. Experiments have demonstrated that iPS cells could be generated using expression plasmids expressing NANOG, Sox2, KlfF4 and c-Myc, eliminating the need for virus introduction, thereby addressing a safety concern for potential use of iPS cells in regenerative medicine. When overexpressed, NANOG promotes cells to enter into S phase and proliferation. Diseases associated with dysfunction in the NANOG protein include tetracarcinoma and germ cell/embryonal cancer.
Spezifikation

Spezifikation

og
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
Q9H9S0
og Homeobox; Homeobox Transcription Factor og; FLJ12581
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
hog.2
Unconjugated
NANOG
Liquid
NANOG
IgG1, kappa
100 μg
4° C
Primary
79923
Videos
Dokumentation

For Research Use Only.