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Descrizione
The MRPs-BCRP Vesicular Transport Assay Reagent Set is a ready-to-use kit containing all reagents needed for vesicular transport assay except for the vesicles themselves. The reagent set can be used for vesicular transport assay using radioisotope-labeled or non-labeled compound. This kit has enough material to perform 100 vesicular transport assays.
Use The MRPs-BCRP Vesicular Transport Assay Reagent Set to:
Investigate the transporter interactions of your drug candidates
Assess potential for transporter-mediated drug-drug interactions
Obtain high quality results with a large signal to noise ratios
Concept Behind ABC Transporter Vesicles
ABC transporter vesicles are easy-to-use, efficient reagents for early assessment of a drug candidate’s substrate and drug interaction potential. While ABC transporters typically mediate the export of substrates out of cells, transporters expressed on these inside-out vesicles import substrates into the vesicles. It is therefore possible to quantitatively evaluate transport activity for your compound by determining the amount incorporated into the vesicles.
Clear and Reliable Results
Prepared from Sf9 cells which have been engineered to over-express specific ABC transporters, these 'inside-out' vesicles provide high levels of transporter activity with low background, giving you a clear signal if your compound is a substrate or inhibitor of a specific efflux transporter.
Kit Compatibility
Our MRPs-BCRP Vesicular Transport Assay Reagent Set is designed for use with either MRP or BCRP Vesicles. The 100 vesicular transport assays that can be performed with this kit will require two MRP or BCRP Vesicle products.
For Research Use Only. Not intended for animal or human therapeutic or diagnostic use.
Use The MRPs-BCRP Vesicular Transport Assay Reagent Set to:
Concept Behind ABC Transporter Vesicles
ABC transporter vesicles are easy-to-use, efficient reagents for early assessment of a drug candidate’s substrate and drug interaction potential. While ABC transporters typically mediate the export of substrates out of cells, transporters expressed on these inside-out vesicles import substrates into the vesicles. It is therefore possible to quantitatively evaluate transport activity for your compound by determining the amount incorporated into the vesicles.
Clear and Reliable Results
Prepared from Sf9 cells which have been engineered to over-express specific ABC transporters, these 'inside-out' vesicles provide high levels of transporter activity with low background, giving you a clear signal if your compound is a substrate or inhibitor of a specific efflux transporter.
Kit Compatibility
Our MRPs-BCRP Vesicular Transport Assay Reagent Set is designed for use with either MRP or BCRP Vesicles. The 100 vesicular transport assays that can be performed with this kit will require two MRP or BCRP Vesicle products.
For Research Use Only. Not intended for animal or human therapeutic or diagnostic use.
Specifica
Specifica
| Content And Storage | Store at -20°C. |
| Formato | Frozen |
| Quantità | 100 assays |
| Shipping Condition | Dry Ice |
| Tipo | Vesicular Transport Assay Reagent Set |
For Research Use Only. Not for use in diagnostic procedures.
Titolo del prodotto
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