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Gibco™ Mouse VEGF-165 Recombinant Protein, PeproTech®

E. coli Recombinant Protein

89.25 CHF - 4330.00 CHF

Spezifikation

Zugriffsnummer Q00731
Zur Verwendung mit (Anwendung) ELISA, Functional Assay, Western Blot
Zusammensetzung protein with no preservative
Gen-ID (Entrez) 22339
Molekulargewicht 39
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Produkte 7
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
17894053
Unterlagen ansehen
Gibco™
450-32-100UG
100 μg
868.00 CHF
100 Mikrogramm
Verfügbar ab: 02-01-2025
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17824803
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Gibco™
450-32-10UG
10 μg
217.00 CHF
10 Mikrogramm
Lager vorrätig
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17824223
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Gibco™
450-32-1MG
1 mg
4330.00 CHF
1 Milligramm
Verfügbar ab: 02-01-2025
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17814803
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Gibco™
450-32-250UG
250 μg
1518.00 CHF
250 Mikrogramm
Verfügbar ab: 02-01-2025
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17814513
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Gibco™
450-32-2UG
2 μg
89.25 CHF
2 Mikrogramm
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17864683
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Gibco™
450-32-500UG
500 μg
2600.00 CHF
500 Mikrogramm
Verfügbar ab: 02-01-2025
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17834573
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Gibco™
450-32-50UG
50 μg
522.00 CHF
50 Mikrogramm
Lager vorrätig
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Beschreibung

Beschreibung

VEGF (vascular endothelial growth factor) which is a 45 kDa homodimeric, disulfide-linked glycoprotein involved in angiogenesis which promotes tumor progression and metastasis. VEGF has a variety of effects on vascular endothelium, including the ability to promote endothelial cell viability, mitogenesis, chemotaxis, and vascular permeability. The VEGF family currently includes VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, and PIGF. VEGF and its receptor system have been shown to be the fundamental regulators in the cell signaling of angiogenesis. Most tumors have the absolute requirement of angiogenesis, and VEGF has been described as the most potent angiogenic cytokine linked to this process. To date 5 different isoforms of VEGF have been described. These isoforms are generated as the result of alternative splicing from a single VEGF gene. These various isoforms have been shown to bind to two tyrosine-kinase receptors flt-1 (VEGFR-1) and flk-1/KDR (VEGFR-2), which have been found to be expressed almost exclusively on endothelial cells. VEGF and its high-affinity binding receptors, the tyrosine kinases FLK1 and FLT1, are thought to be important for the development of embryonic vasculature. Studies have shown that an alternately spliced form of FLT1 produces a soluble protein, termed sFLT1, which binds vascular endothelial growth factor with high affinity, playing an inhibitory role in angiogenesis. Elevated levels of VEGF is linked to POEMS syndrome (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy, Skin changes) also known as Crow-Fukase syndrome which affects multiple organs in the body.
Spezifikation

Spezifikation

Q00731
protein with no preservative
39
E. coli
RUO
angiogenic factor; etID309976.16; eVEGF120; eVEGF164; human VEGF121 homolog; MGC70609; MVCD1; ovine vascular endothelial growth factor; RP1-261G23.1; unnamed protein product; VAS; vascular endothelial growth factor; vascular endothelial growth factor (VEGF) precursor; vascular endothelial growth factor 121 isoform; vascular endothelial growth factor 164; vascular endothelial growth factor 165 b; vascular endothelial growth factor 182; vascular endothelial growth factor 182 isoform; vascular endothelial growth factor 188; vascular endothelial growth factor 188 isoform; vascular endothelial growth factor 189; vascular endothelial growth factor A; vascular endothelial growth factor A121; vascular endothelial growth factor A165; vascular endothelial growth factor Aa; Vascular endothelial growth factor A-A; vascular endothelial growth factor isoform 165; vascular permeability factor; Vasculotropin; VEGF; VEGF1; VEGF164; VEGF182; VEGF188; vegfa; VEGF-A; VEGFA165b; vegfaa; VEGF-A-A; VEGFMGC70
Mouse
Recombinant
Lyophilized
ELISA, Functional Assay, Western Blot
22339
Mouse VEGF-165
-20°C
<1 EU/μg
VEGFA
Unconjugated
MAPTTEGEQK SHEVIKFMDV YQRSYCRPIE TLVDIFQEYP DEIEYIFKPS CVPLMRCAGC CNDEALECVP TSESNITMQI MRIKPHQSQH IGEMSFLQHS RCECRPKKDR TKPEKHCEPC SERRKHLFVQ DPQTCKCSCK NTDSRCKARQ LELNERTCRC DKPRR
≥ 98% by SDS-PAGE gel and HPLC analyses.
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