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ACROBiosystems Mouse RENIN Protein, His Tag

Marke:  ACROBiosystems REN-M5222-1MG

Additional Details : Gewicht : 0.00001kg

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Artikelnummer. 15827587

  • 2072.64 CHF / 1 Milligramm


Verfügbar ab
28-05-2021
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Beschreibung

Beschreibung

Renin is also known as REN and angiotensinogenase, is a circulating enzyme that participates in the body's renin-angiotensin system (RAS), and plays an essential role in the elevation of arterial blood pressure and increased sodium retention by the kidney. Renin activates the renin-angiotensin system by cleaving angiotensinogen, produced by the liver, to yield angiotensin I, which is further converted into angiotensin II by ACE, the angiotensin-converting enzyme primarily within the capillaries of the lungs. Renin is secreted from kidney cells, which are activated via signaling from the macula densa, which responds to the rate of fluid flow through the distal tubule, by decreases in renal perfusion pressure (through stretch receptors in the vascular wall), and by sympathetic nervous stimulation, mainly through beta-1 receptor activation. Renin can bind to ATP6AP2, which results in a fourfold increase in the conversion of angiotensinogen to angiotensin I over that shown by soluble renin. In addition, renin binding results in phosphorylation of serine and tyrosine residues of ATP6AP2. The level of renin mRNA appears to be modulated by the binding of HADHB, HuR and CP1 to a regulatory region in the 3' UTR. An over-active renin-angiotension system leads to vasoconstriction and retention of sodium and water. These effects lead to hypertension. Therefore, renin inhibitors can be used for the treatment of hypertension.

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 37.0 kDa. The protein migrates as 47-57 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Spezifikation

Spezifikation

NP_112469.1
HEK293
Mouse
37.0 kDa
1 mg
Leu 22 - Arg 402
REN,FLJ10761,Renin,angiotensinogenase
Unconjugated
PBS, pH7.4
Less than 1.0 EU / µg by the LAL method.
Enzymes
Powder
>95% as determined by SDS-PAGE
Mouse RENIN, His Tag (REN-M5222) is expressed from human 293 cells (HEK293). It contains AA Leu 22 - Arg 402 (Accession # NP_112469.1). The propeptide sequence is AA Leu 22 - Thr 71.
-20°C
RENIN
His Tag
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation