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ACROBiosystems Mouse PD-1 / PDCD1 Protein, Mouse IgG2a Fc Tag
auf Anfrage
Spezifikation
Zugriffsnummer | NP_032824 |
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Molekulargewicht | 43.7 kDa |
Quelle | Mouse PD-1, Mouse IgG2a Fc Tag (PD1-M52A4) is expressed from human 293 cells (HEK293). It contains AA Ser 21 - Gln 167 (Accession # NP_032824). |
Immunogen | Ser 21 - Gln 167 |
Lagerungsbedingungen | -20°C |
Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
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Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
15817497
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ACROBiosystems
PD1-M52A4-1MG |
1 mg |
auf Anfrage
1 Milligramm |
N/A | |||||
Dieser Artikel erfordert eine Preisaktualisierung, bevor er bestellt werden kann. Fordern Sie hier einen Preis für diesen Artikel an. |
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15807497
|
ACROBiosystems
PD1-M52A4-100UG |
100 μg |
Dieser Artikel wurde eingestellt und ist leider nicht mehr verfügbar. Sehen Sie sich das Produkt an, um alternative Produktvorschläge zu sehen oder kontaktieren Sie unseren Technischen Support unter 056 618 41 11. |
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Beschreibung
Programmed cell death protein 1 (PD-1) is also known as CD279 and PDCD1, is a type I membrane protein and is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 is expressed on the surface of activated T cells, B cells, macrophages, myeloid cells and a subset of thymocytes. PD-1 has two ligands, PD-L1 and PD-L2, which are members of the B7 family. PD-L1 is expressed on almost all murine tumor cell lines, including PA1 myeloma, P815 mastocytoma, and B16 melanoma upon treatment with IFN-γ. PD-L2 expression is more restricted and is expressed mainly by DCs and a few tumor lines. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. In vitro, treatment of anti-CD3 stimulated T cells with PD-L1-Ig results in reduced T cell proliferation and IFN-γ secretion. Monoclonal antibodies targeting PD-1 that boost the immune system are being developed for the treatment of cancer.
This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 43.7 kDa. The protein migrates as 55-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Spezifikation
NP_032824 | |
Mouse PD-1, Mouse IgG2a Fc Tag (PD1-M52A4) is expressed from human 293 cells (HEK293). It contains AA Ser 21 - Gln 167 (Accession # NP_032824). | |
-20°C | |
PD-1 | |
Mouse | |
PBS, pH7.4 | |
HEK293 | |
Immune Checkpoint Proteins |
43.7 kDa | |
Ser 21 - Gln 167 | |
PDCD1,PD1,CD279,SLEB2 | |
Unconjugated | |
Mouse IgG Fc Tag | |
Less than 0.1 EU / μg by the LAL method. | |
Powder | |
>90% as determined by SDS-PAGE |