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ACROBiosystems Mouse LAIR1 / CD305 Protein, Mouse IgG2a Fc Tag, low endotoxin
low endotoxin
441.35 CHF - 2938.13 CHF
Spezifikation
Zugriffsnummer | NP_001106945.1 |
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Molekulargewicht | 40.6 kDa |
Quelle | Mouse LAIR-1, Mouse IgG2a Fc Tag, low endotoxin (LA1-M5254) is expressed from human 293 cells (HEK293). It contains AA Gln 22 - Tyr 141 (Accession # Q8BG84-1). |
Immunogen | Gln 22 - Tyr 141 |
Lagerungsbedingungen | -20°C |
Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
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Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
16467819
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ACROBiosystems
LA1-M5254-1MG |
1 mg |
2938.13 CHF
1 Milligramm |
Verfügbar ab: 10-05-2024
Loggen Sie sich ein, um den Lagerbestand zu sehen |
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15827207
|
ACROBiosystems
LA1-M5254-100UG |
100 μg |
441.35 CHF
100 Mikrogramm |
Verfügbar ab: 10-05-2024
Loggen Sie sich ein, um den Lagerbestand zu sehen |
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Beschreibung
Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is constitutively expressed on the majority of human peripheral blood mononuclear leukocytes. LAIR-1 or CD305 is a transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs. LAIR-1 recruits SHP-1 and SHP-2 phosphatases upon activation, and cross-linking of the LAIR-1 antigen on natural killer (NK) cells results in strong inhibition of NK cell–mediated cytotoxicity. Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation.Diseases associated with LAIR1 include Chronic Active Epstein-Barr Virus Infection and Palindromic Rheumatism.
This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 40.6 kDa. The protein migrates as 50-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Spezifikation
NP_001106945.1 | |
Mouse LAIR-1, Mouse IgG2a Fc Tag, low endotoxin (LA1-M5254) is expressed from human 293 cells (HEK293). It contains AA Gln 22 - Tyr 141 (Accession # Q8BG84-1). | |
-20°C | |
LAIR-1 | |
Mouse | |
50 mM Tris, 100 mM Glycine, pH7.5 | |
HEK293 | |
Immune Checkpoint Proteins |
40.6 kDa | |
Gln 22 - Tyr 141 | |
LAIR1,CD305 | |
Unconjugated | |
Mouse IgG Fc Tag | |
Less than 0.1 EU / μg by the LAL method. | |
Powder | |
>95% as determined by SDS-PAGE |