missing translation for 'onlineSavingsMsg'
Learn More

ACROBiosystems Mouse LAIR1 / CD305 Protein, Mouse IgG2a Fc Tag, low endotoxin

low endotoxin

Marke:  ACROBiosystems LA1-M5254-100UG

Additional Details : Gewicht : 0.00001kg

 Lernen Sie weitere Varianten dieses

Artikelnummer. 15827207

  • 403.01 CHF / 100 Mikrogramm


Verfügbar ab
28-05-2021
Zum Warenkorb hinzufügen

Beschreibung

Beschreibung

Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is constitutively expressed on the majority of human peripheral blood mononuclear leukocytes. LAIR-1 or CD305 is a transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs. LAIR-1 recruits SHP-1 and SHP-2 phosphatases upon activation, and cross-linking of the LAIR-1 antigen on natural killer (NK) cells results in strong inhibition of NK cell–mediated cytotoxicity. Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation.Diseases associated with LAIR1 include Chronic Active Epstein-Barr Virus Infection and Palindromic Rheumatism.

This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 40.6 kDa. The protein migrates as 50-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Spezifikation

Spezifikation

NP_001106945.1
HEK293
Mouse
40.6 kDa
100 µg
Gln 22 - Tyr 141
LAIR1,CD305
Unconjugated
50 mM Tris, 100 mM Glycine, pH7.5
Less than 0.1 EU / µg by the LAL method.
Immune Checkpoint Proteins
Powder
>95% as determined by SDS-PAGE
Mouse LAIR-1, Mouse IgG2a Fc Tag, low endotoxin (LA1-M5254) is expressed from human 293 cells (HEK293). It contains AA Gln 22 - Tyr 141 (Accession # Q8BG84-1).
-20°C
LAIR-1
Mouse IgG Fc Tag
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation